Biopolym. Cell. 2011; 27(6):423-431.
http://dx.doi.org/10.7124/bc.000112
Огляди
Фенотипи Drosophila melanogaster, зумовлені порушеннями функціонування дистрофіну та дистроглікану
1Рішко В. М., 1Голуб Н. Я., 1Черник Я. І.
  1. Львівський національний університет імені Івана Франка
    Вул. Грушевського, 4, Львів, Україна, 79005

Abstract

Основні компоненти дистрофін-глікопротеїнового комплексу – дистрофін і дистроглікан – необхідні для нормальної життєдіяльності D. melanogaster упродовж усього онтогенезу. Мутації в генах цих білків спричиняють різні фенотипи, серед проявів яких є ознаки, характерні для м’язової дистрофії людини. Крім того, описано низку відмінних фенотипів, вивчення яких проливає світло на розуміння перебігу різних патологій, дає змогу виявляти нові компоненти у складі дистрофін-глікопротеїнового комплексу та нові регуляторні білки, що впливають на функціонування цього комплексу. Таким чином, на основі генетичного об’єкта D. melanogaster створено хорошу модельну систему для вивчення міопатій людини.
Keywords: Drosophila melanogaster, дистрофін-глікопротеїновий комплекс, м’язові дистрофії, експресія дистрофіну (дистроглікану)
Повний текст: (PDF, українською)

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