Biopolym. Cell. 2011; 27(6):423-431.
Огляди
Фенотипи Drosophila melanogaster, зумовлені порушеннями функціонування дистрофіну та дистроглікану
1Рішко В. М., 1Голуб Н. Я., 1Черник Я. І.
- Львівський національний університет імені Івана Франка
Вул. Грушевського, 4, Львів, Україна, 79005
Abstract
Основні компоненти дистрофін-глікопротеїнового комплексу – дистрофін і дистроглікан – необхідні для нормальної життєдіяльності D. melanogaster упродовж усього онтогенезу. Мутації в генах цих білків спричиняють різні фенотипи, серед проявів яких є ознаки, характерні для м’язової дистрофії людини. Крім того, описано низку відмінних фенотипів, вивчення яких проливає світло на розуміння перебігу різних патологій, дає змогу виявляти нові компоненти у складі дистрофін-глікопротеїнового комплексу та нові регуляторні білки, що впливають на функціонування цього комплексу. Таким чином, на основі генетичного об’єкта D. melanogaster створено хорошу модельну систему для вивчення міопатій людини.
Keywords: Drosophila melanogaster, дистрофін-глікопротеїновий комплекс, м’язові дистрофії, експресія дистрофіну (дистроглікану)
Повний текст: (PDF, українською)
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