Молекулярні механізми розвитку клітинної інсулінорезистентності

Ракша, Н. Г.; Савчук, О. М.; Остапченко, Л. І.

doi:10.7124/bc.000106

Biopolym. Cell. 2011; 27(4):249-257.

http://dx.doi.org/10.7124/bc.000106

Огляди

Молекулярні механізми розвитку клітинної інсулінорезистентності

1Ракша Н. Г., 1Савчук О. М., 1Остапченко Л. І.

Навчально-науковий центр «Інститут біології»
Київського національного університету імені Тараса Шевченка
вул. Володимирська, 64/13, Київ, Україна, 01601

Abstract

Розглянуто деякі патогенетичні механізми, які обумовлюють формування стану клітинної інсулінорезистентності на рецепторному та пострецепторному рівнях. Особливу увагу приділено аналізу факторів, що впливають на функціонування компонентів фосфатидилінозитольної ланки інсулінового сигнального каскаду.

Keywords: інсулінорезистентність, субстрати інсулінового рецептора, фосфатидилінозитол-3-кіназа, серинове фосфорилювання

Повний текст: (PDF, українською)

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