Протеїнкіназа ASK1 як перспективна мішень для фармакологічного втручання

Волинець, Г. П.; Бджола, В. Г.; Кухаренко, О. П.; Совєтова, О. В.; Ярмолюк, С. М.

doi:10.7124/bc.0007DA

Biopolym. Cell. 2009; 25(3):169-180.

http://dx.doi.org/10.7124/bc.0007DA

Огляди

Протеїнкіназа ASK1 як перспективна мішень для фармакологічного втручання

1Волинець Г. П., 1Бджола В. Г., 1Кухаренко О. П., 1Совєтова О. В., 1Ярмолюк С. М.

Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Протеїнкіназа ASK1 (Apoptosis signal-regulating kinase 1) – серин/треонінова кіназа 5 кінази МАР-кінази (MAPKKK5), яка зустрічається в усіх евкаріотних організмах. ASK1 індукує апоптоз через каскади JNK і p38 у відповідь на проапоптичні стимули – активні форми оксигену, TNF-α, Fas, стрес ендоплазматичного ретикулуму та ін. ASK1 бере участь у процесах диференціації та загибелі нейронів. Кіназа є важливою сигнальною молекулою в гіпертрофії та апоптозі кардіоміоцитів. ASK1 залучена до розвитку імунної відповіді та до процесів старіння ендотеліальних клітин при діабеті і може бути потенційною терапевтичною мішенню для попередження старіння судин, лікування нейродегенеративних і серцевих хвороб.

Keywords: ASK1, апоптоз, диференціація, імунна відповідь, гіпертрофія серця

Повний текст: (PDF, українською) (PDF, англійською)

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