Biopolym. Cell. 2007; 23(3):215-242.
http://dx.doi.org/10.7124/bc.000767
Мутації – це що?
1Кордюм В. А.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Проналізовано уявлення про мутації. Наведено літературні дані, які не відповідають існуючим концепціям мутацій. Сформульовано положення стосовно функціональної неоднозначності мутацій та їхнього біологічного значення. Згідно з цим положенням, мутації у сомі виконують регуляторні функції, являючи собою, таким чином, нормальну, контрольовану організмом, складову біологічних процесів. А при виході з-під контролю мутації в сомі призводять до онкогенезу. У зародковому ж шляху мутації через каскадні інтегральні процеси забезпечують елімінацію їхніх носіїв, виконуючи очищувальну функцію. А при виході з-під контролю, не спричинюючи элімінації їхніх носіїв, реалізуються у спадкову патологію в усьому її діапазоні – від прихованої форми («мутаційний вантаж») до ярскравої маніфестації.
Keywords: мутації, регуляція, сома, зародковий шлях
Повний текст: (PDF, російською) (PDF, англійською)

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