Biopolym. Cell. 2007; 23(3):155-166.
Сучасна картина спонтанного мутагенезу та можливе місце в ній природної таутомерії основ ДНК
1Черепенко О. Й., 1Говорун Д. М.
- Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680
Abstract
В обзорі сумовано загальноприйняті у сучасній генетиці дані з вивчення різноманітних джерел спонтанного мутагенезу, який визначається внутрішньоклітинними процесами життєдіяльності клітини за будь-яких умов її функціонування. Охарактеризовано механізми виникнення переважного числа класів мутацій, а також можливі механізми регуляції швидкості спонтанного мутагенезу. Аналіз даних значного підвищення пулу дНТФ за умов генотоксичного стресу і відповідного зростання рівня мутацій у таких клітинах дозволяє пояснити цей результат ефектами таутомеріії основ ДНК, які виникають при скупченні цих молекул у тісному молекулярному просторі. Припускається, що контроль над швидкістю спонтанного мутагенезу може бути пов’язаним з контролем над концентрацією дНТФ у клітині.
Keywords: спонтанний мутагенез, таутомерія основ ДНК, рівні внутрішньоклітинного пулу дНТФ
Повний текст: (PDF, російською) (PDF, англійською)
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