Biopolym. Cell. 2007; 23(1):14-20.
Клітинна біологія
Синтез 2’-5’-олiгоаденiлатiв та їхнiй вплив на пролiферацiю i мiграцiю стовбурових клiтин кiсткового мозку мишей in vitro та in vivo
- Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680
Abstract
Фосфотриефiрним методом у розчинi синтезовано 2’-5’-триаденiлат та його 3’-епоксианалог. Встановлено, що цi препарати стимулюють мiграцiю стовбурових клiтин кiсткового мозку мишей-донорiв та їхнє включення у селезiнку мишей-реципiєнтiв при сингеннiй трансплантацiї in vivo. 2’-5’-Oлiгоаденiлати та їхнi похiднi залежно вiд препарату i його концентрацiї впливають на апоптоз i пролiферацiю клiтин кiсткового мозку мишей in vitro.
Keywords: 2’-5’-олiгоаденiлати, аналоги олiгонуклеотидiв, мiграцiя, стовбуровi клiтини, пролiферацiя, апоптоз
Повний текст: (PDF, українською) (PDF, англійською)
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