Biopolym. Cell. 2006; 22(1):75-81.
http://dx.doi.org/10.7124/bc.00071E
Біоінформатика
Аналіз розподілу мобільних генетичних елементів у гені ТР53 людини та його 5-фланкованій ділянці
1Підпала О. В., 1Яцишина А. П., 1Лукаш Л. Л.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Проведено комп'ютерний аналіз розповсюдження мобільних генетичних елементів (МГЕ) в гені ТР53 людини та його 5'-фланкованій ділянці. Не виявлено суттєвої різниці для SINE- і LINE-елементів, однак з'ясовано, що LINE J-елементи присутні винятково в межах гена, тоді як LINE2 — переважно у 5'-фланкованій ділянці. Серед МГЕ найчастіше зустрічаються Alu-повтори. Зовсім не знайдено LTR-елементів, а ДНК-транспозони у незначній кількості представлені лише в гені. Як у межах гена, так і його 5'-фланкованій ділянці МГЕ переважно формують кластерні мозаїчні структури, до складу яких входять елементи різних родин та підродин.
Keywords: ген TP53 людини, мобільні генетичні елементи, Alu-повтори, кластерні мозаїчні структури.
Повний текст: (PDF, українською) (PDF, англійською)

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