Biopolym. Cell. 2004; 20(1-2):93-105.
http://dx.doi.org/10.7124/bc.000697
Регуляція мінливості геному соматичних клітин ссавців під впливом екзогенних біологічних чинників
1Лукаш Л. Л.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Проаналізовано результати досліджень, які демонструють, що біологічні чинники довкілля здатні індукувати мутації, здійснюючи при цьому регуляторно-інформаційний вплив на клітинні системи підтримання генетичної стабільності: реплікацію, рекомбінацію, репарацію. Серед біологічних факторів, що дестабілізують клітинний геном, особливо виокремлюються мобільні генетичні елементи та онкогенні віруси, які спричиняють злоякісну трансформацію клітин. Висловле­но припущення стосовно того, що зміна програм генної експресії при диференціюванні стовбурових клітин у спе­ціалізовані супроводжується запуском процесів мутаційної і рекомбінаційної мінливості
Повний текст: (PDF, російською)

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