Biopolym. Cell. 2004; 20(1-2):78-91.
http://dx.doi.org/10.7124/bc.000695
Структурна біоінформатика в постгеномну еру
1Одинець К. О., 1Івахно С. С., 1Ковальський Д. Б., 1Токовенко Б. Т., 1Корнелюк О. І.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Структурна біоінформатика – це нова галузь молекулярної біології, яка використовує методи комп'ютерного аналізу для моделювання просторової структури білків і макромолекулярних комплексів для з'ясування їхніх функцій. Метою структурної біоінформатика є також створення селективних модуляторів функціональної активності білків як нових лікарських препаратів. Прогрес структурної біоінформатики обумовлений бурхливим розвитком геноміки – розишфровкою декількох сотень геномів про- та еукаріотних організмів і переходом біології в постгеномну еру. В огляді розглянуто такі питання, як моделювання просторової структури білків, протеоміка та інтерактоміка, біоінформатика при аналізі транскриптому, молекулярна динаміка білків, моделювання взаємодій з лігандами, комп'ютерний дизайн лікарських препаратів тощо. Описано застосування цих підходів при дослідженні тирозил-тРНК синтетази ссавців та протеази вірусу імунодефіциту людини. Подано інформацію про перший український біоінформаційний web-портал BioUA, який створено для проведення досліджень у галузі геноміки та структурної біоінформатики.
Повний текст: (PDF, українською)

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