Biopolym. Cell. 1986; 2(6):283-292.
http://dx.doi.org/10.7124/bc.0001C5
Огляди
ДНК: надспіралізація і утворення неканонічних структур
1Лазуркін Ю. С.
  1. Інститут молекулярної генетики АН СРСР
    Москва, СРСР

Abstract

Наведено огляд робіт з вивчення впливу надспіралізації на структуру і властивості ДНК. Показано, що під дією надспіралізації в ДНК утворюються три альтернативні, неканонічні структури: хрестоподібна, Z-форма і Н-форма (нова структура, що виникає в гомопурин-гомопіримідинових послідовностях). Переконливі докази утворення цих структур in vitro отримано останніми роками за допомогою методу двовимірного гель-електрофорезу. Їхнє формування у надспіральних ДНК тісно пов’язане зі специфічними білками, які зумовлюють їхню стабілізацію. Ці білки, ймовірно, відіграють важливу роль у регуляції генної активності.
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