Biopolym. Cell. 2003; 19(4):307-316.
http://dx.doi.org/10.7124/bc.000663
Огляди
Інфекційний лейкоз великої рогатої худоби та його діагностика
1Стародуб М. Ф., 1Стародуб В. М.
  1. Інститут біохімії ім. О. В. Палладіна НАН України
    вул. Леонтовича, 9, Київ, Україна, 01601

Abstract

В огляді наведено дані щодо розповсюдження вірусного лейкозу великої рогатої худоби та характеристика його збудника. Коротко розглянуто відомості про молекулярно-генетичні та імунологічні властивості вірусу. Особливу увагу приділено біохімічній діагностиці інфекційного лейкозу з використанням традиційних серологічних методів та методу полімеразної ланцюгової реакції. Описано також сучасні інструментальні серологічні методи діагностики лейкозу, розроблені на основі принципів біосенсорики. Зроблено порівняльний аналіз існуючих та наново створюваних методів біохімічної діагностики дано­го захворювання.
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References

[1] Wu MC, Shanks RD, Lewin HA. Milk and fat production in dairy cattle influenced by advanced subclinical bovine leukemia virus infection. Proc Natl Acad Sci U S A. 1989;86(3):993-6.
[2] McNab WB, Jacobs RM, Smith HE. A serological survey for bovine immunodeficiency-like virus in Ontario dairy cattle and associations between test results, production records and management practices. Can J Vet Res. 1994; 58(1): 36-41.
[3] Huber NL, DiGlacomo BF, Evermann JF, Studer E. Bovine leukemia virus infection in a large Holstein herd. I. Cohort analysis of the prevalence of antibody-positive cows. II. Prospective comparison of production and reproductive performance in antibody-negative and antibody-positive cows. Am J Vet Res. 1981; 42:1474-81.
[4] D'Angelino JL, Garcia M, Birgel EH. Productive and reproductive performance in cattle infected with bovine leukosis virus. J Dairy Res. 1998;65(4):693-5.
[5] Busol VO. Veterinary-sanitary problems of leukemia cows milk and meat. Vet Med Ukrainy. 2002;4-5.
[6] Sparling AM. An unusual presentation of enzootic bovine leukosis. Can Vet J. 2000;41(4):315-6.
[7] Donham KJ, Berg JW, Sawin RS. Epidemiologic relationships of the bovine population and human leukemia in Iowa. Am J Epidemiol. 1980;112(1):80-92.
[8] Trono KG, P?rez-Filgueira DM, Duffy S, Borca MV, Carrillo C. Seroprevalence of bovine leukemia virus in dairy cattle in Argentina: comparison of sensitivity and specificity of different detection methods. Vet Microbiol. 2001;83(3):235-48.
[9] Van Der Maaten MJ, Miller JM, Boothe AD. Replicating type-C virus particles in monolayer cell cultures of tissues from cattle with lymphosarcoma. J Natl Cancer Inst. 1974;52(2):491-7. PubMed PMID: 8396281.
[10] Bel?k S, Ballagi-Pord?ny A. Application of the polymerase chain reaction (PCR) in veterinary diagnostic virology. Vet Res Commun. 1993;17(1):55-72.
[11] Radke K. Bovine leukemia virus. Encyclopedia of virology. Eds R. G. Webster, A. Granoff. New York: Acad, press, 1994: 166-174.
[12] Snider TG, Hoyt PG, Jenny BF, Coats KS, Luther DG, Storts RW, Battles JK, Gonda MA. Natural and experimental bovine immunodeficiency virus infection in cattle. Vet Clin North Am Food Anim Pract. 1997;13(1):151-76. PubMed PMID: 1963391.
[13] Evermann JF. Comparative features of retroviral infections of livestock. Comp Immunol Microbiol Infect Dis. 1990;13(3):127-36.
[14] Chevallier N, Berthelemy M, Le Rhun D, Lain? V, Levy D, Schwartz-Cornil I. Bovine leukemia virus-induced lymphocytosis and increased cell survival mainly involve the CD11b+ B-lymphocyte subset in sheep. J Virol. 1998;72(5):4413-20.
[15] Twizere JC, Kerkhofs P, Burny A, Portetelle D, Kettmann R, Willems L. Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo. J Virol. 2000;74(21):9895-902.
[16] Stone DM, Norton LK, Davis WC. Spontaneously proliferating lymphocytes from bovine leukaemia virus-infected, lymphocytotic cattle are not the virus-expressing lymphocytes, as these cells are delayed in G(0)/G(1) of the cell cycle and are spared from apoptosis. J Gen Virol. 2000;81(Pt 4):971-81.
[17] Stone DM, Norton LK, Chambers JC, Meek WJ. CD4 T lymphocyte activation in BLV-induced persistent B lymphocytosis in cattle. Clin Immunol. 2000;96(3):280-8.
[18] Dusinsk? R, Bardotti M, Ponti W. Decreased expression of L-selectin (CD62L) on lymphocytes in enzootic bovine leukaemia. J Vet Med B Infect Dis Vet Public Health. 2000;47(2):127-32.
[19] Lundberg P, Splitter GA. gammadelta(+) T-Lp6phocyte cytotoxicity against envelope-expressing target cells is unique to the alymphocytic state of bovine leukemia virus infection in the natural host. J Virol. 2000;74(18):8299-306.
[20] Garvey KJ, Oberste MS, Elser JE, Braun MJ, Gonda MA. Nucleotide sequence and genome organization of biologically active proviruses of the bovine immunodeficiency-like virus. Virology. 1990;175(2):391-409.
[21] Altaner C, Merza M, Altanerova V, Morein B. Envelope glycoprotein gp51 of bovine leukemia virus is differently glycosylated in cells of various species and organ origin. Vet Immunol Immunopathol. 1993;36(2):163-77.
[22] Johnson R, Kaneene JB. Bovine leukemia virus and enzootic bovine leukosis. Vet Bull. 1992; 4:287-311.
[23] Dequiedt F, Hanon E, Kerkhofs P, Pastoret PP, Portetelle D, Burny A, Kettmann R, Willems L. Both wild-type and strongly attenuated bovine leukemia viruses protect peripheral blood mononuclear cells from apoptosis. J Virol. 1997;71(1):630-9.
[24] Kerkhofs P, Heremans H, Burny A, Kettmann R, Willems L. In vitro and in vivo oncogenic potential of bovine leukemia virus G4 protein. J Virol. 1998;72(3):2554-9.
[25] Tajima S, Aida Y. The region between amino acids 245 and 265 of the bovine leukemia virus (BLV) tax protein restricts transactivation not only via the BLV enhancer but also via other retrovirus enhancers. J Virol. 2000;74(23):10939-49.
[26] Blankenstein P, Bondzio A, Fechner H, Beier D, Marquardt O, Looman AC, Ebner D. A nucleotide deletion causing a translational stop in the protease reading frame of bovine leukaemia virus (BLV) results in modified protein expression and loss of infectivity. J Vet Med B Infect Dis Vet Public Health. 2000;47(5):361-71.
[27] Willems L, Kerkhofs P, Attenelle L, Burny A, Portetelle D, Kettmann R. The major homology region of bovine leukaemia virus p24gag is required for virus infectivity in vivo. J Gen Virol. 1997;78 (Pt 3):637-40.
[28] Portetelle D, Bruck C, Mammerickx M, Burny A. Use of monoclonal antibody in an ELISA test for the detection of antibodies to bovine leukaemia virus. J Virol Methods. 1983;6(1):19-29.
[29] Gatei MH, Naif HM, Kumar S, Boyle DB, Daniel RC, Good MF, Lavin MF. Protection of sheep against bovine leukemia virus (BLV) infection by vaccination with recombinant vaccinia viruses expressing BLV envelope glycoproteins: correlation of protection with CD4 T-cell response to gp51 peptide 51-70. Virol. 1993 ; 67(4): 1803–1810.
[30] Cowley JA, Molloy JB, Dimmock CK, Walker PJ, Bruyeres AG, Ward WH. Infectivity of bovine leukaemia virus infected cattle: an ELISA for detecting antigens expressed in in vitro cultured lymphocytes. Vet Microbiol. 1992;30(2-3):137-50.
[31] Llames L, Gomez-Lucia E, Domenech A, De Avila A, Suarez G, Goyache J. Production and Characterization of Monoclonal Antibodies against Bovine Leukaemia Virus using Various Crude Antigen Preparations: a Comparative Study. J Vet Med Series B. 2000;47(5):387–97.
[32] Lienau A, St?ber M, Kehrli ME, Tammen I, Schwenger B, Kuczka A, Pohlenz J. [Bovine leukocyte adhesion deficiency: clinical picture and differential diagnosis]. Dtsch Tierarztl Wochenschr. 1994;101(10):405-6.
[33] Fundamental Immunology. Ed Paul WE. Raven Press New York 1984
[34] Mager A, Masengo R, Mammerickx M, Letesson JJ. T cell proliferative response to bovine leukaemia virus (BLV): identification of T cell epitopes on the major core protein (p24) in BLV-infected cattle with normal haematological values. J Gen Virol. 1994;75 (Pt 9):2223-31.
[35] Orlik O, Ban J, Hlavaty J, Altaner C, Kettmann R, Portetelle D, Splitter GA. Polyclonal bovine sera but not virus-neutralizing monoclonal antibodies block bovine leukemia virus (BLV) gp51 binding to recombinant BLV receptor BLVRcp1. J Virol. 1997;71(4):3263-7.
[36] Levkut M, Ponti W, Soligo D, Quirici N, Rocchi M, Lambertenghi Deliliers G. Expression and quantification of IgG and IgM molecules on the surface of lymphocytes of cattle infected with bovine leukaemia virus. Res Vet Sci. 1995;59(1):45-9.
[37] Hopkins SG, DiGiacomo RF. Natural transmission of bovine leukemia virus in dairy and beef cattle. Vet Clin North Am Food Anim Pract. 1997;13(1):107-28.
[38] Fukai K, Sato M, Kawara M, Hoshi Z, Ueno S, Chyou N, Akashi H. A case of an embryo transfer calf infected with bovine leukemia virus from the recipient cow. Zentralbl Veterinarmed B. 1999;46(8):511-5.
[39] Mandigra M. Genetic aspects of bovine leukemia. Vet Med Ukrainy. 2000; 18-9.
[40] Miller JM, Van Der Maaten MJ. Use of glycoprotein antigen in the immunodiffusion test for bovine leukemia virus antibodies. Eur J Cancer. 1977;13(12):1369-75.
[41] Miller JM, Schmerr MJ, Van Der Maaten MJ. Comparison of four serologic tests for the detection of antibodies to bovine leukemia virus. Am J Vet Res. 1981;42(1):5-8.
[42] Franz J, Hampl J, Hof?rek B, Skrob?k F, Svoboda I, Gran?tov? M. [Radioimmunologic detection of antibodies to bovine leukemia virus]. Vet Med (Praha). 1986;31(8):459-68.
[43] Hoff-J?rgensen R. An international comparison of different laboratory tests for the diagnosis of bovine leukosis: suggestions for international standardization. Vet Immunol Immunopathol. 1989;22(3):293-7.
[44] Dolz G, Moreno E. Comparison of agar gel immunodiffusion test, enzyme-linked immunosorbent assay and western blotting for the detection of BLV antibodies. Zentralbl Veterinarmed B. 1999;46(8):551-8.
[45] Simard C, Richardson S, Dixon P, B?langer C, Maxwell P. Enzyme-linked immunosorbent assay for the diagnosis of bovine leukosis: comparison with the agar gel immunodiffusion test approved by the Canadian Food Inspection Agency. Can J Vet Res. 2000;64(2):101-6.
[46] Dom?nech A, Llames L, Goyache J, Su?rez G, G?mez-Luc?a E. Comparison of four tests to evaluate the reactivity of rabbit sera against envelope or Gag-related proteins of bovine leukemia virus (BLV). Vet Microbiol. 1998;60(1):13-25.
[47] Nguyen VK, Maes RF. Evaluation of an enzyme-linked immunosorbent assay for detection of antibodies to bovine leukemia virus in serum and milk. J Clin Microbiol. 1993;31(4):979-81.
[48] Carli KT, Sen A, Batmaz H, Kennerman E. Detection of IgG antibody to bovine leukaemia virus in urine and serum by two enzyme immunoassays. Lett Appl Microbiol. 1999;28(6):416-8.
[49] Llames L, Goyache J, Domenech A, de Avila A, Suarez G, Gomez-Lucia E. Rapid detection of specific polyclonal and monoclonal antibodies against bovine leukemia virus. J Virol Methods. 1999;82(2):129-36.
[50] Sargeant JM, Kelton DF, Martin SW, Mann ED. Evaluation of a bulk-milk ELISA test for the classification of herd-level bovine leukemia virus status. Prev Vet Med. 1997;31(3-4):223-30.
[51] Rod?k L, Gran?tov? M, Vesel? T, Nevor?nkov? Z. Monoclonal antibody for the demonstration by ELISA of antibodies to protein p24 of enzootic bovine leukosis virus in individual and pooled blood serum and milk samples. Zentralbl Veterinarmed B. 1997;44(7):425-36.
[52] Kittelberger R, Reichel MP, Meynell RM, Tham KM, Molloy JB. Detection of antibodies against the core protein p24 of the bovine leukaemia virus in cattle for confirmatory serological testing. J Virol Methods. 1999;77(1):109-14.
[53] Merza M, Sundquist B, S?ber J, Morein B. Immunoaffenity purification of two major proteins of bovine leukemia virus (gp51 and p24) and their use for discrimination between vaccinated and infected animals. Journal of Virological Methods. 1991;33(3):345–53.
[54] Mikalauskene GI, Va?chiunene VV, Peshkus IuK, Tamoshiunas VI. [Preparation of monoclonal antibodies to gp51 antigen and their use for early diagnosis of bovine leukemia]. Ukr Biokhim Zh. 1996;68(3):89-94.
[55] Zheng L, Swanson M, Liao J, Wood C, Kapil S, Snider R, Loughin TA, Minocha HC. Cloning of the bovine immunodeficiency virus gag gene and development of a recombinant-protein-based enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol. 2000;7(4):557-62.
[56] Vidziunait? R, Dikinien? N, Miliukien? V, Mikulskis P, Kulys J. Chemiluminescence ELISA for the detection of antibodies to bovine leukaemia virus antigens. J Biolumin Chemilumin. 1995;10(3):193-8.
[57] M?ller M, Wittmann W. [Cost-benefit analysis of the control and cure of enzootic bovine leukosis, described in the example of a selected territory]. Arch Exp Veterinarmed. 1990;44(2):213-22.
[58] Yarchuk BM, Dombrovs'kyy OB, Tyrsin RV, Kornienko LE, Dovgal OV. Bovine leukemia. Biblioteka Vet Med. 2000;9(12):62.
[59] Mandigra M, Kurtok B, Simonov R. Scientific and practical basis of many years experience with leukemia cattle farms Lviv region. Vet Med Ukrainy. 1999;10-11.
[60] Ignatov MM, Chvanov OM, Prylepskiy SV, Pyasyk ON, Lopata EP. Improvement measures against leukemia. Vet Med Ukrainy. 2001;38-9.
[61] Gylyukin MI, Zamareva NV, Abramov VN, Barabanov NI. Status and prospects of the fight against bovine leukemia. Veterinaria. 1999;12: 3-8.
[62] Burkhardt H, Rosenthal S, Wittmann W, Starick E, Scholz D, Rosenthal HA, Kluge KH. [Immunization of young cattle with gp51 of the bovine leukosis virus and the subsequent experimental infection]. Arch Exp Veterinarmed. 1989;43(6):933-42.
[63] Ohishi K, Kabeya H, Amanuma H, Onuma M. Peptide-based bovine leukemia virus (BLV) vaccine that induces BLV-Env specific Th-1 type immunity. Leukemia. 1997;11 Suppl 3:223-6.
[64] Wagner HJ, Blankenstein P, Bondzio A, Ebner D, Risse S. Increase of antigen production in BLV-infected cell lines via additional expression of tax. Zentralbl Veterinarmed B. 1995;42(9):543-50.
[65] Llames L, Goyache J, Domenech A, Arjona A, Suarez G, Gomez-Lucia E. Evaluation of virus excretion by cells persistently infected with the bovine leukaemia virus (BLV) using monoclonal antibodies. J Clin Virol. 2001;22(1):31-9.
[66] AS. USSR N 6795. A method for producing a vaccine against bovine leukemia. LI Nagaeva. Publ. 16.07.1993.
[67] Nagaeva LI, Kovalyushko VS, Priskoka VA, Adamenko OP, Aranchiy SV, Pedora VG, Saglo OS, Ilyukha AP. The results of studies of a vaccine against bovine leukemia. Materials Betw. scientific. Conf. "General epizootology: immunological, environmental and methodological problems" (20-22 Sept 1995). Kharkov, 1995;401-3.
[68] Nagaeva LI, Tsymbal VI, Aranchiy SV, Pedora VG, Saglo ES, Ilyukha AP, Dobrosal GI. Scientific Production introduction of a vaccine against bovine leukemia in a complex of measures to be healed e n uw of bovine leukemia. Materials Betw. scientific. Conf. "General epizootology: immunological, environmental and methodological problems" (20-22 Sept 1995). Kharkov, 1995;404-407.
[69] Kerkhofs P, Gatot JS, Knapen K, Mammerickx M, Burny A, Portetelle D, Willems L, Kettmann R. Long-term protection against bovine leukaemia virus replication in cattle and sheep. J Gen Virol. 2000;81(Pt 4):957-63.
[70] Reichert M, Cantor GH, Willems L, Kettmann R. Protective effects of a live attenuated bovine leukaemia virus vaccine with deletion in the R3 and G4 genes. J Gen Virol. 2000;81(Pt 4):965-9.
[71] Babiuk LA, Lewis J, Suradhat S, Baca-Estrada M, Foldvari M, Babiuk S. Polynucleotide vaccines: potential for inducing immunity in animals. J Biotechnol. 1999;73(2-3):131-40.
[72] Ballagi-Pord?ny A, Klintevall K, Merza M, Klingeborn B, Bel?k S. Direct detection of bovine leukemia virus infection: practical applicability of a double polymerase chain reaction. Zentralbl Veterinarmed B. 1992;39(1):69-77.
[73] Jacobs RM, Song Z, Poon H, Heeney JL, Taylor JA, Jefferson B, Vernau W, Valli VE. Proviral detection and serology in bovine leukemia virus-exposed normal cattle and cattle with lymphoma. Can J Vet Res. 1992;56(4):339-48.
[74] Eaves FW, Molloy JB, Dimmock CK, Eaves LE. A field evaluation of the polymerase chain reaction procedure for the detection of bovine leukaemia virus proviral DNA in cattle. Vet Microbiol. 1994;39(3-4):313-21.
[75] Klintevall K, Ballagi-Pord?ny A, N?slund K, Bel?k S. Bovine leukaemia virus: rapid detection of proviral DNA by nested PCR in blood and organs of experimentally infected calves. Vet Microbiol. 1994;42(2-3):191-204.
[76] Beier D, Blankenstein P, Fechner H. [Possibilities and limitations for use of the polymerase chain reaction (PCR) in the diagnosis of bovine leukemia virus (BLV) infection in cattle]. Dtsch Tierarztl Wochenschr. 1998;105(11):408-12.
[77] Fechner H, Kurg A, Geue L, Blankenstein P, Mewes G, Ebner D, Beier D. Evaluation of polymerase chain reaction (PCR) application in diagnosis of bovine leukaemia virus (BLV) infection in naturally infected cattle. Zentralbl Veterinarmed B. 1996;43(10):621-30.
[78] Fechner H, Kurg A, Blankenstein P, Mewes G, Geue L, Albrecht C, Ebner D. Direct use of cell lysates in PCR-based diagnosis of bovine leukemia virus infection. Berl Munch Tierarztl Wochenschr. 1996;109(11-12):446-50.
[79] Martin D, Arjona A, Soto I, Barquero N, Viana M, G?mez-Luc?a E. Comparative study of PCR as a direct assay and ELISA and AGID as indirect assays for the detection of bovine leukaemia virus. J Vet Med B Infect Dis Vet Public Health. 2001;48(2):97-106.
[80] Oblap RV, Glazko VI, Sozinov AA. [The bovine leukosis virus and the diagnosis of infected animals]. Tsitol Genet. 1997;31(2):41-3.
[81] Blankenstein P, Fechner H, Looman AC, Beier D, Marquardt O, Ebner D. [Polymerase chain reaction (PCR) for detection of BLV provirus-- a practical complement for BLV diagnosis?]. Berl Munch Tierarztl Wochenschr. 1998;111(5):180-6.
[82] Zhang S, Troyer DL, Kapil S, Zheng L, Kennedy G, Weiss M, Xue W, Wood C, Minocha HC. Detection of proviral DNA of bovine immunodeficiency virus in bovine tissues by polymerase chain reaction (PCR) and PCR in situ hybridization. Virology. 1997;236(2):249-57.
[83] Guti?rrez SE, Dolcini GL, Arroyo GH, Rodriguez Dubra C, Ferrer JF, Esteban EN. Development and evaluation of a highly sensitive and specific blocking enzyme-linked immunosorbent assay and polymerase chain reaction assay for diagnosis of bovine leukemia virus infection in cattle. Am J Vet Res. 2001;62(10):1571-7.
[84] Gulyukin MI, Zamoraeva NV, Ivanova LA, Grek KP, Simonov AV, Barkova NV. Methods of diagnosis of bovine leukemia. Veterinar Gazeta. 2001;12:1-2.
[85] Starodub MF, Artyukh VL, Pirogova LV, Nagaeva LI, Dobrosol GI, Pavlenko MS, Grotevich VO. Express diagnosis of bovine leukemia based bio sensory analysis. Vet Med Ukrainy. 2001; 11: 26-7.
[86] Starodub NF, Pirogova LV, Artyukh VP, Starodub VM. Biospecific interactions on the optical transducer surface-the base of infection diagnostics. Frontiers of multifunctional nanosystems: Proc. of NATO ARW. Eds E. Buzaneva, P. Scharff. Dordrecht, Boston, London: Kluwer Acad, press, 2002;2: 369-76.