Biopolym. Cell. 2002; 18(6):467-477.
http://dx.doi.org/10.7124/bc.000629
Огляди
Створення продуцентів нових полікетидних антибіотиків методами генетичної інженерії
1Осташ Б. О., 1Федоренко В. О.
  1. Львівський національний університет імені Івана Франка
    вул. Грушевського, 4, Львів, Україна, 79005

Abstract

Зроблено огляд сучасних експериментальних даних в галузі вивчення біосинтезу полікетидів – однієї з найбільших груп природних сполук, що проявляють широкий спектр цінних біологічних властивостей. Розуміння генетичних та біохімічних аспектів полікетидного синтезу дозволяє створити рекомбінантні штами мікроорганізмів, що продукують нові сполуки з передбачуваною структурою. Описано основні методи генетичного «дизайну» нових полікетидних сполук, наведено приклади геноінженерного конструювання продуцентів промислово важливих полікетидних ан­тибіотиків.
Повний текст: (PDF, українською)

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