Biopolym. Cell. 2000; 16(6):525-529.
Клітинна біологія
Експресія гена дефенсину-6 (HD-6) у лініях пухлинних клітин людини
1Лісовський І. Л., 1Хобта А. І., 1Солдаткіна М. А., 1Литвин Д. І., 1Маркеєва Н. В., 2Сидорик Л. Л., 1Погрібний П. В.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680
  2. Інститут експериментальної патології, онкології і радіобіології ім. Р. Є. Кавецького
    вул. Васильківська, 45, Київ, Україна, 03022

Abstract

У роботі досліджено експресію гена дефенсину-6 (HD-6) у злоякісно трансформованих лініях клітин людини різного гістогенезу: А431 (епідермальна карцинома)у САМ (Т-клітин­на лімфома), Molt-4 (Т-клітинна лімфома), KB ( епідермоїдна карцинома), HeLa ( епітеліоїдна карцинома), Colo 320HSR (аденокарцинома), U251 (гліобластома). З використанням методу RT-PCR виявлено експресію даного гена в усіх вищезаз­начених лініях клітин. Отримані результати дозволяють припустити, що деякі види неопластичної трансформації клітин спричинюють дерегуляцію експресії генів дефенсинів, зокрема, гена HD-6.

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