Biopolym. Cell. 2000; 16(3):186-194.
Огляди
Імуногенетичні аспекта синдрому Дауна
1Заставна Д. В., 1Терпиляк О. І., 1Гнатейко О. З.
  1. Інститут спадкової патології АМН України
    вул. М. Лисенка, 31а, Львів, МСП-169, Україна, 79008

Abstract

В огляді розглянуто імуногенетичні аспекти одного з найвідоміиіих анеуплоїдних хромосомних захворювань – хвороби Дауна. Грунтуючись на тому, що імунологічна індивідуальність організму і відповідно схильність до того чи іншого захворювання обумовлені функцією антигенів головного комплексу гістосумісності, в представленій роботі зроблено акценти на аналізі особливостей розподілу HLA-антигенів при формуванні хвороби Дауна в комплексі з іншими регуляторними чинниками, такими, зокрема, як інтерферон. Досліджується також питання можливої участі аутоімунних тиреоїдитів як фактора ризику формування анеуплоїдної хромосомної патологи в потомстві людини.

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