Biopolym. Cell. 1999; 15(6):467-480.
http://dx.doi.org/10.7124/bc.000541
Огляди
Регуляція генів інтерферонів І типу та інтерферон-індукованих генів. Білкові фактори промоторних транскрипційних комплексів
1Карпов О. В.
  1. Інститут мікробіології і вірусології ім. Д. К. Заболотного НАН України
    вул. Академіка Заболотного, 154, Київ, Україна, 03680

Abstract

Наведено огляд відомостей стосовно характеристики білкових транскрипційних факторів, що беруть участь у регуляції індукованої експресії генів інтерферонів I типу (α- і β-ІФН), а також ІФН-індукованих генів. Описано відомі структурні характеристики та субодиничний склад таких факторів, їхні контакти з регуляторними доменами відповідних промоторів, а також білок-білкові взаємодії і їхню роль у генній експресії. Наведено також загальну картину експресії генівα /β-ІФН та ІФН-індукованих генів у відповідь на індукцію. З огляду на останні дані підкреслено значення складної просторової структури транскрипційного комплексу (енхансеосоми) з викори­станням відносно незалежних, але пов'язаних між собою груп транскрипційних факторів, що дає змогу організмові специфічно реагувати на зовнішні фактори (вірусна інфекція тощо).
Повний текст: (PDF, українською)

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