Biopolymers and Cell

Biopolym. Cell. 1999; 15(4):262-274.

http://dx.doi.org/10.7124/bc.000523

Огляди

Чи регулює окис азоту процес передачі сигналу від фактора некрозу пухлин?

1Оболенська М. Ю., 1Самійленко А. А.

Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Огляд присвячено аналізу можливої ролі окису азоту в процесах сприйняття і внутрішньо клітинної передачі сигналу від фактора некрозу пухлин (ФНП). Наведено дані про сумісну участь ФНП і окису азоту в різних фізіологічних та патофізіологічних процесах. Розглядаються альтернативні шляхи передачі сигналу від ФНП, шр призводять або до загибелі клітин, або до розвитку компенсаторних реакцій, які забезпечують життєздатність клітин. Детально проаналізовано особливості структури білків – посередників у передачі сигналу від ФНП, які визначають можливість їхньої взаємодії з окисом азоту. На основі здійсненого аналізу і існуючих даних про взаємодію деяких посередників з окисом азоту висловлюється припущення стосовно участі окису азоту в прояві різноманітних функцій ФНП.

Повний текст: (PDF, українською)

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