Biopolym. Cell. 1998; 14(6):540-543.
Структура та функції біополімерів
Індуковані радіацією тканиноспецифічні особливості вмісту мРНК цитохрому Р4502Е1 та онкогенів у щура
1Прима В. І., 1Глушакова Л. Г.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Вивчали експресію гена цитохрому CYP2E1 а також онкогенів c-myc і c-fos у різних органах щурів лінії Wistar, що утримувалися в умовах Чорнобильської зони відчуження. При порівняні даних для дослідних і контрольних груп тварин виявлено вірогідні розбіжності в експресії вказаних генів на рівні РНК

References

[1] Prima VI, Clochko TA, Obolenskaya MYu, Ivanov PL, Ryskov AP, Platonov OM. Synchronous changes of c-fos RNA and B2+mRNAx concentrations during prereplicative period in regenerating rat liver. Biopolym Cell. 1989; 5(6):83-6.
[2] Bishop JM. Viral oncogenes. Cell. 1985;42(1):23-38. Review.
[3] Koblyakov VA. Cytochromes of the P-450 family and their role in procancerogenes activation. Moscow: VINITI, 1990: 3-190.
[4] Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 1979;18(24):5294-9.
[5] Maniatis T, Fritsch EF, Sambrook J. Molecular Cloning. A Laboratory Manual. New York: Cold Spring Harbour Lab. press, 1982.
[6] Feinberg AP, Vogelstein B. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem. 1984;137(1):266-7.
[7] Church GM, Gilbert W. Genomic sequencing. Proc Natl Acad Sci U S A. 1984;81(7):1991-5.
[8] Curran T, Peters G, Van Beveren C, Teich NM, Verma IM. FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA. J Virol. 1982;44(2):674-82.
[9] Vennstrom B, Sheiness D, Zabielski J, Bishop JM. Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29. J Virol. 1982;42(3):773-9.
[10] Ryskov AP, Ivanov PL, Kramerov DA, Georgiev GP. Mouse ubiquitous B2 repeat in polysomal and cytoplasmic poly(A)+RNAs: uniderectional orientation and 3'-end localization. Nucleic Acids Res. 1983;11(18):6541-58.
[11] Hollander MC, Fornace AJ Jr. Induction of fos RNA by DNA-damaging agents. Cancer Res. 1989;49(7):1687-92.
[12] Herrlich P, Angel P, Jobst Rahmsdorf H, Mallick U, P?ting A, Hieber L, et al. The mammalian genetic stress response. Advances in Enzyme Regulation. 1986;25:485-8.
[13] Stein B, Rahmsdorf HJ, Steffen A, Litfin M, Herrlich P. UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol. 1989;9(11):5169-81.
[14] Woloschak GE, Chang-Liu CM. Differential modulation of specific gene expression following high- and low-LET radiations. Radiat Res. 1990;124(2):183-7.
[15] Munson GP, Woloschak GE. Differential effect of ionizing radiation on transcription in repair-deficient and repair-proficient mice. Cancer Res. 1990;50(16):5045-8.
[16] Koropatnick J, Leibbrand M, Cherian MG. Organ-specific metallothionein induction in mice by X irradiation. Radiat Res. 1989;119(2):356-65.
[17] * Baraboi V. A., Oliynyk S. A., Khmelevsky Yu. V. The state of antioxidant system under the action of low dose and low intensity ionizing radiation. Ukr Biokhim Zh. 1994. 66(4):3-18.
[18] Burlakova EB. Radiobiological consequences of nuclear accidents: contamination, radioecology, radiobioiogy and health. Radiat. Protection Dosimetry. New York: Nucl. Technol. publ. 1995. 62: 13-18.
[19] Obolenskaya MYu, Tschaikovskaya TL, Lebedeva LM, Macewicz LL, Didenko LV, Decker K. Glutathione status of placentae from differently polluted regions of Ukraine. Eur J Obstet Gynecol Reprod Biol. 1997;71(1):23-30.
[20] Obolenskaia MIu, Prima VI, Klochko TA, Pater LV, Shokolenko IN, Platonov OM. Cycle dependent expression of the gene coding for B2mRNA. Mol Gen Mikrobiol Virusol. 1991;(6):30-2.
[21] Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993;12(1):1-51.
[22] Yang CS, Tu YY, Koop DR, Coon MJ. Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes. Cancer Res. 1985;45(3):1140-5.
[23] Umeno M, Song BJ, Kozak C, Gelboin HV, Gonzalez FJ. The rat P450IIE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5' cytosine demethylation. J Biol Chem. 1988;263(10):4956-62.