Biopolym. Cell. 1998; 14(6):500-511.
Огляди
Мутагенез і антимутагенез – протилежно спрямовані процеси, що визначають рівень генетичної мінливості та стабільності
- Інститут молекулярної біології і генетики НАН України
Вул. Академіка Заболотного, 150, Київ, Україна, 03680
Abstract
Розглянуто такі, питання: актуальність проблеми захисту генетичних структур людина від токсичних і мутагенних факторів довкілля, становлення мутаційної теорії та виокремлення проблеми антимутагенезу реалізація впливу генетично активних факторів довкілля на різних рівнях організації біосистем, механізми адаптації організму до зміни зовнішніх умов і фармакологічний захист геному, коротка характеристика генетично активних біологічних факторів особливості антимутагенів природного походження.
Повний текст: (PDF, українською)
References
[1]
Dubinin NP. New in modern genetics. M.: Nauka, 1986; 206 p.
[2]
Bochkov PP, Chebotarev AI. Human heredity and mutagens of the environment. M.: Meditsina. 1989. 270 p.
[3]
Shapiro NI. Genetic mechanisms of carcinogenesis. Vestn Akad Nauk SSSR. 1981; 12:69-75.
[4]
Ayzenzen MG, Aleksandrov YuP, Buzhyevskaya TI et al. Mutagenic effects of natural and synthetic polynucleotides. Kiev: Naukova Dumka 1990. 128 p.
[5]
Kordyum VA. And then I sat down to write this book: It is not usual notions of human genetics. Kiev, 1993; 248 p.
[6]
Barylyak IR, Gavrilyuk YuI. Environment and genetics. Dovkillya ta zdorov'ya. 1996; 1:30-3.
[7]
Serdyuk AM. Ukraine Environmental safety. Dovkillya ta zdorov'ya. 1996; 1: 3-7.
[8]
Vozianov OF. Actual problems of medical science. Dovkillya ta zdorov'ya. 1996;(1):19-21.
[9]
Alekperov UK. Antimutagenesis. M.: Nauka. 1984. 100 p.
[10]
Seredenin SB, Durnev AD. Pharmacological protection of the genome. M.: VINITI, 1992. 160 p.
[11]
Goncharova PI. Antimutagenesis. Minsk: Nauka i tekhnika). 1974; 142 p.
[12]
Auerbach C. Problems of mutagenesis. Moscow: Mir, 1978. 470 p.
[13]
Abilev SK, Poroshenko GG. M.: VINITI (Itogi nauki i tekhniki, Ser Toksikologiia vol 14), 1986. 171 p.
[14]
Khesin RB. Genome instability. Moscow, Nauka, 1984; 472 p.
[15]
Poroshenko GG, Abilev SK. Anthropogenic mutagens and natural antimutagens. M.: VINITI (Itogi nauki i tekhniki; Ser. Obsch genet. vol 12). 1988; 5-206
[16]
Poromenko GG. [Antimutagens: approaches to their classification and prospects in searching of active compounds]. Vestn Ross Akad Med Nauk. 1995;(1):38-41.
[17]
Goncharova RI. [Antimutagenesis as a genetic process]. Vestn Ross Akad Med Nauk. 1993;(1):26-33.
[18]
Zhestannikov VD. DNA repair and its biological significance. Leningrad: Nauka. 1979; 286 p.
[19]
Kada T. Mechanisms and genetic implications OF environmental antimutagens. Environmental antimutagenes and carcinogens. Eds Sigimura T., Kondo S., Takebe H. TOKIO; New: YORK, 1982. P, 355-359.
[20]
Kada T, Shimoi K. Desmutagens and bio-antimutagens--their modes of action. Bioessays. 1987;7(3):113-6.
[21]
De Flora S, Ramel C. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview. Mutat Res. 1988;202(2):285-306.
[22]
Zasukhina GD, Sinel'shchikova TA. [Mutagenesis, antimutagenesis, DNA repair]. Vestn Ross Akad Med Nauk. 1993;(1):9-14.
[23]
Ramel C, Alekperov UK, Ames BN, Kada T, Wattenberg LW. International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Publication No. 12. Inhibitors of mutagenesis and their relevance to carcinogenesis. Report by ICPEMC Expert Group on Antimutagens and Desmutagens. Mutat Res. 1986;168(1):47-65.
[24]
Pentiuk AA, Durnev AD, Matviĭchuk NV, Gutsol VI, Iavorskiĭ AN, Shcherbaniuk VV, Seredenin SB. [Vitamin A and enzyme systems of metabolic activation of genotoxic compounds]. Vestn Ross Akad Med Nauk. 1995;(1):3-9.
[25]
Butenko ZA, Nikolayenko IN. Retinoides as inductors of differentiation of leukaemic cells. Eksp Oncol. 1991; 13(2):3-9.
[26]
Vasilieva SV, Davnitschenko LS, Rapoport IA. Intensification of DNA repair processes by para-aminobenzoic acid in Escherichia coli K-12. Genetika. 1982, 18(3):381–91.
[27]
Wilpart M, Speder A, Ninane P, Roberfroid M. Antimutagenic effects of natural and synthetic hormonal steroids. Teratog Carcinog Mutagen. 1986;6(4):265-73.
[28]
Alldrick AJ, Rowland IR, Wise A. The hepatic conversion of some heterocyclic amines to bacterial mutagens is modified by dietary fat and cholesterol. Mutagenesis. 1987;2(3):221-4.
[29]
Lalchev Cm Cytogenetic evaluation antimutagenic activity of Phs in vivo. Sovrem Med. 1987; 38(12): 14-6.
[30]
Lukash LL, Karpova IS, Miroshnichenko OS, Tikhonova TN, Lylo VV, Man'ko VG, Sukhorada EM, Golynskaia EL. [The effect of the lectin from Sambucus nigra inflorescences on spontaneous and alkylating agent-induced mutagenesis in mammalian somatic cells]. Tsitol Genet. 1997;31(5):52-60.
[31]
Sen P, Costa M. Pathway of nickel uptake influences its interaction with heterochromatic DNA. Toxicol Appl Pharmacol. 1986;84(2):278-85.
[32]
Ranchialis VP, Bal'chiunene LS. [Paradoxical effects of thiol compounds]. Vestn Ross Akad Med Nauk. 1995;(1):44-9.
[33]
Murray M. Mechanisms of the inhibition of cytochrome P-450-mediated drug oxidation by therapeutic agents. Drug Metab Rev. 1987;18(1):55-81.
[34]
Cassand P, Alzieu P, Perret V, Robertson LW, Narbonne JF. Modifying effect of vitamin A on benzo[a]pyrene mutagenicity induced by polychlorinated biphenyls. Mutat Res. 1987;181(2):328–9.
[35]
Ong TM, Whong WZ, Stewart J, Brockman HE. Chlorophyllin: a potent antimutagen against environmental and dietary complex mixtures. Mutat Res. 1986;173(2):111-5.
[36]
Arimoto S, Ohara Y, Hiramoto K, Hayatsu H. Inhibitory effect of myoglobin and hemoglobin on the direct-acting mutagenicity of protein pyrolysate heterocyclic amine derivatives. Mutat Res. 1987;192(4):253-8.
[37]
Locknitskaya NN, Rotenberg YuS, Fonstein LM, Shulyakovskaya TS. The study of the process of biotransformation of promutagens by the Ames test. III. On the role of conjugation with glucoronic acid and sulfate in modification of the mutagenic action of diethyl nitrosoamine, nitrosomorpholine and cyclophosphane. Genetika. 1986; 22(9):2259-64.
[38]
Weitberg AB. The effect of L-2-oxothiazolidine on glutathione levels in cultured mammalian cells. Mutat Res. 1987;191(3-4):189-91.
[39]
Stepuro II. [Antioxidant properties of vitamins and their complex with blood proteins]. Vopr Med Khim. 1992;38(4):26-33.
[40]
Summerfield FW, Tappel AL. Vitamin E protects against methyl ethyl ketone peroxide-induced peroxidative damage to rat brain DNA. Mutat Res. 1984;126(2):113-20.
[41]
Fariss MW. Oxygen toxicity: unique cytoprotective properties of vitamin E succinate in hepatocytes. Free Radic Biol Med. 1990;9(4):333-43.
[42]
Weitberg AB. Effect of combinations of antioxidants on oxygen radical-induced sister chromatid exchanges. Clin Genet. 1987;32(2):114-7.
[43]
Kuzhir TD, Goncharova RI. [Mechanisms of the inhibitive action of 1,4-dihydroisonicotinic acid derivatives in chemical mutagenesis]. Vestn Ross Akad Med Nauk. 1995;(1):20-9.
[44]
Tomilin NV. The genetic stability of cells. Leningrad: Nauka, 1983. 156 p.
[45]
Zasukhina GD. Cell repair mechanisms and problems of the environment. M.: Nauka, 1979. 184 p.
[46]
Generoso WM, Cain KT, Krishna M, Huff SW. Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg. Proc Natl Acad Sci U S A. 1979;76(1):435-7.
[47]
Vasil'eva SV, Davnichenko LS, Lutskova EV, Rapoport IA. [Reparative effect of the genetically active natural compound p-aminobenzoic acid in an experiment with N-nitrosomethylurea]. Dokl Akad Nauk SSSR. 1979;247(1):226-30.
[48]
Gichner T, V?leminsk? J, Rapoport IA, Vasilieva SV. Antimutagenic effect of p-aminobenzoic acid on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine in Salmonella typhimurium. Mutat Res. 1987;192(2):95-8.
[49]
Zasukhina GD, Barkova EP, Shvetsova TP, Andronova AV, Bektemirov TA. [In vitro effect of interferon on the formation of chromosome aberrations and the mitotic activity of human diploid cells exposed to 4-nitroquinoline-1-oxide]. Vopr Virusol. 1979;(5):544-7.
[50]
Suzuki N, Suzuki H. Suppression of UV mutagenicity by human interferon. Mutat Res. 1988;202(1):179-83.
[51]
Chekova VV, Zasukhina GD. [Interferon stimulation of DNA reparative synthesis in human cells with an inhibited repair system]. Dokl Akad Nauk SSSR. 1989;309(5):1238-40.
[52]
Zolotareva GN, Loginova NS, Radchenko LU. Influence timotropina stimulating interferon formation, processes of spontaneous and induced mutations in mammalian cells. Tez, Dokl. section genet. aspects of the problems. "Man and the Biosphere". Kiev, 1988:53.
[53]
Zolotareva GN, Loginova NS, Radchenko LU. Correction of mutagenic properties of medicines in the experiment using interferon inducers. Metod, i metodol. vopr. genetiki. Tomsk, 1990; 132-142.
[54]
Kiuchi H, Inoue T, Kada T, Makino O, Shibata T, Ando T. Effect of an antimutagenic metal compound, cobaltous chloride, on E. coli RecA protein in vitro. Mutat Res. 1984;130(5):367–8.
[55]
Inoue T, Kada T. Bioantimutagemc effect of L-ethioninc ON the spontaneous mutagenesis in Salmonella and Bacillus suhtilis. Annu Reps Nat Inst Genet Jap. 1987. Misima: 67.
[56]
Zhurkov VS. M.: VINITI (Itogo Nauki i Tekhniki, ser Genetika cheloveka vol 2), 1975:116-61.
[57]
Obana H, Nakamura S, Tanaka R. Suppressive effect of food on the induced SOS responses. Mutat Res. 1987;182(6):372.
[58]
Dixit R, Gold B. Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid. Proc Natl Acad Sci U S A. 1986;83(21):8039-43.
[59]
Quintiliani M, Sapora O, Maggi A. Int J Radiat Biol. 1984; 46(5): 649-654.
[60]
Dubinin NP, Shcherbakov VK. [Controlling the natural mutation process using cysteamine and streptomycin]. Dokl Akad Nauk SSSR. 1962; 145(2):427-9.
[61]
Samson L, Cairns J. A new pathway for DNA repair in Escherichia coli. Nature. 1977;267(5608):281-3.
[62]
Montesano R, Br?sil H, Planche-Martel G, Margison GP, Pegg AE. Effect of chronic treatment of rats with dimethylnitrosamine on the removal of O6-methylguanine from DNA. Cancer Res. 1980;40(2):452-8.
[64]
Waldstein EA, Cao EH, Setlow RB. Adaptive increase of O6-methylguanine-acceptor protein in HeLa cells following N-methyl-N'-nitro-N-nitrosoguanidine treatment. Nucleic Acids Res. 1982;10(15):4595-604.
[65]
Morimoto K, Sato-Mizuno M, Koizumi A. Adaptation-like response to the chemical induction of sister chromatid exchanges in human lymphocytes. Hum Genet. 1986;73(1):81-5.
[66]
Rieger R, Michaelis A, Takehisa S. “Clastogenic cross-adaptation” is dependent on the clastogens used for induction of chromatid aberrations in Vicia faba root-tip meristems. Mutat Res Lett. 1985;144(3):171–5.
[67]
Schubert I, Rieger R, Michaelis A. Effects of 'G2-repair' inhibitors on 'clastogenic adaptation' in Vicia faba. Mol Gen Genet. 1986;204(1):174–9.
[68]
Dubinina LG, Kurashova ZI, Sergievskaya SP. The influence of pretreatment with non-mutagenic doses of ethyleneimine on mutagenesis in Crepis capillaris cells. Genetika. 1986;22(12):2805-12.
[69]
Kundiev YuI. Occupational diseases - a threat to the nation. Svit NAN Ukrainy: ostanni novyny. 1997;6:8.
[70]
Bobyleva LA, Chopikashvili LV, Alekhina NI, Zasukhina GD. [Modification with ascorbic acid of the level of spontaneous and induced chromosome aberrations and sister chromatid exchanges in lymphocytes of workers in contact with molybdenum salts]. Genetika. 1993;29(3):430-4.
[71]
Peresadin NA, Frolov VM, Pinskiĭ LL. [The antioxidant correction of cytogenetic disorders in viral hepatitis]. Lik Sprava. 1995;(1-2):76-9.
[72]
Durnev AD, Seredenin SB. [The pharmacological problems of searching for and using antimutagens]. Vestn Ross Akad Med Nauk. 1993;(1):19-26.
[73]
Gershenson SM, Alexandrov YuN, Malyuta SS. Mutagenic Effect of DNA and viruses in Drosophila. Kiev: Naukova Dumka, 1975; 160 p.
[74]
Ilinskih NN, Bocharov EF, Ilinskih IN. Infectious mutagenesis. Novosibirsk: Nauka. 1984. 108 p.
[75]
Buzhievskaya TI, Lukash LL. Biological mutagens environment. Genet. effects of environmental pollution. Kiev: Naukova Dumka.1989: 121-43.
[76]
Shapiro NI, Marshak MI, Varshaver NB. Mutagenic effects of DNA-containing oncogenic viruses and malignant transformation of mammalian cells. Cancer Genet Cytogenet. 1984;13(2):167-79.
[77]
Lukash LL, Varshaver NB, Buzhiyevskaya TI, Shapiro NI. The oncogene of BAV-3 as a mutagen. J Cell Sci. 1985;78:97-103.
[78]
Lukash LL, Buzhievskaya TI. Role of early viral genes in mutagenesis. Biotechnol. Curr Progr Lancaster: Techn Publ Comp., 1991: 119-31.
[79]
Schramayr S, Caporossi D, Mak I, Jelinek T, Bacchetti S. Chromosomal damage induced by human adenovirus type 12 requires expression of the E1B 55-kilodalton viral protein. J Virol. 1990;64(5):2090-5.
[80]
Gazaryan KG. Microinjection of genes in embryos: integration into the genome and genetic effects. Usp sovrem genet. 1985;13:75-88.
[81]
Gershenson SM, Alexandrov YuN. Molecular mechanisms of mutagenicity of DNA and other natural and synthetic polynucleotides. Kyiv: NAS of Ukraine, 1997. 264 p.
[82]
Bobrysheva IV, Baron EM, Varshaver NB. [Role of activated cellular c-Ha-ras-1 oncogene in the mutagenic effect of the plasmid pEJ6.6]. Genetika. 1992;28(8):5-12.
[83]
Bobrysheva IV, Baron EM, Varshaver NB. [Plasmid pSVc-myc-1 induces gene mutations and chromosome aberrations in cultured Chinese hamster cells]. Tsitol Genet. 1993;27(4):51-5.
[84]
Bobrysheva IV, Varshaver NB. [Characteristics of mutants induced by the c-Ha-ras1 oncogene and the nature of the oncogene's mutagenic action]. Genetika. 1995;31(12):1598-604.
[85]
Lukash LL, Podolskaya SV, Suhorada HM, Kostetskaya KV, Kostetsky IE, Varzanova IS, Patskovsky YuV, Vavilina IV, Deis SV. The influence of alkylating agent MNNG on mutagenic effect of exogeneous recombinant DNA. Biopolym Cell. 1995; 11(1):87-91.
[86]
Rubashevsky EL, Patskovsky YuV, Kirilenko SD, Varzanova IS, Bogolyubova OM, Lysenko OF, Lukash LL. DNA recombinant molecules carrying different allels of human preproinsulin gene as mutagens in Chinese hamster cells. Biopolym Cell. 1996; 12(5):83-92.
[87]
Bariliak IR, Isaeva AV. [The antimutagenic and gene-protective properties of preparations of plant origin]. Tsitol Genet. 1994;28(3):3-17.
[88]
Salikhova RA, Poroshenko GG. [Antimutagenic properties of Angelica archangelica L]. Vestn Ross Akad Med Nauk. 1995;(1):58-61.
[89]
Timchenko OI, Borshchevskaia MI, Ianchevskaia NV. [The modifying action of a complex of physiologically active substances isolated from the human amnion on chromosome damage]. Tsitol Genet. 1995;29(5):49-54.
[90]
Kunakh VA. About herbal medicine, ecology and cell biotechnology or rebirth of medicinal plants. Svit. 1997;5:8.
[91]
Timchenko OI, Antipenko EN. [Conditions for using thyroxine as an antimutagen after whole-body x-ray irradiation]. Radiobiologiia. 1981;21(2):204-10.
[92]
Timchenko OI. Identification and evaluation of mutagenic effects of low-energy physical factors: the role of hormonal homeostasis: Auth Thesis. ... dr med nauk. Kiev, 1991; 42 p.
[93]
Koveshnikova IV, Antipenko EN. [The role of the thyroid hormones in regulating chromosomal resistance to microwave exposure]. Radiobiologiia. 1992;32(4):512-5.
[94]
Rushkovskiĭ SR, Chegrinets SE, Bezrukov VF, Khrapunov SN. [The effect of thymogen on the chromosome aberration level in a culture of human peripheral blood lymphocytes]. Tsitol Genet. 1996;30(5):81-5.
[95]
Markel AL, Borodin PM. Stress as a factor reflation genetic variability. Ontogenet. and genetic-evolution. aspects of the neuroendocrine stress regulation. Novosibirsk: Nauka, 1990; 148-59.
[96]
Tkachev AV. Aspects of radiation damage to the thyroid gland: Author. Thesis. ... dr biol nauk. L, 1970; 30 p.
[97]
Yarmonenko SP. Radiobiology humans and animals. M.: Vysch Shkola. 1988; 424 p.
[98]
Sergeev PV, Shimanovskiy NYa. Receptots. M.: Meditsina, 1987; 400 p.
[99]
Lukash LL. Approach for detection of the substances with anticarcinogenic and antimutagenic action from natural extracts . Int. Symp. on the Cell Mol Mechanisms of Carcinogenesis and Mutagenesis: Abstracts. 1997: 42.
[100]
Lukash LL, Podolskaya SV, Evseeenko AA, Suhorada HeM, Neborachko LN, Varsanova IS, Kochubei TP. The recombinant DNA pGins that contains expressing human preproinsulin gene has no mutagenic activity. Biopolym Cell. 1999; 15(1):28-37.
[101]
Semenov VV. [Mutagenesis, antimutagenesis and the cellular regulatory system]. Vestn Ross Akad Med Nauk. 1995;(1):41-4.
[102]
Mitanchez D, Doiron B, Chen R, Kahn A. Glucose-stimulated genes and prospects of gene therapy for type I diabetes. Endocr Rev. 1997;18(4):520-40.