Biopolym. Cell. 1998; 14(4):298-319.
http://dx.doi.org/10.7124/bc.0004DB
Геномна мінливість соматичних клітин рослин. 4. Мінливість у процесі дедиференціації і калюсоутворення in vitro
1Кунах В. А.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Зроблено огляд даних стосовно особливостей геномної мінливості при індукції процесів дедиференціації і калюсоутворення. Розглянуто роль генотипу і стану геному в клітинах вихідного експланту, вплив чинників середовища, причини, механізми та. можливі шляхи регуляції цієї мінливості. Показано, що індукція процесів дедиференціації і подальшої проліферації клітин передбачає перепрограмування геному, «ювенілізацію» його стану. Запропоновано гіпотезу щодо регресивної еволюції геному в процесі розвитку програми дедиференціації. Здатність до такої еволюції лежить в основі властивого багатьом рослинам циклу розвитку диференціація– дедиференціація– редиференціація. Існування такого циклу, його регульованість як у природі, так і в експерименті ставить під сумнів тезу про запрограмоване число клітинних циклів, про незворотність старіння, про фатум запрограмованої клітинної смерті та апоптозу. Підкреслюється особлива важливість та актуальність вивчення молекулярних механізмів процесів дедиференціації і ювенілізації на прикладі рослин. Це, на думку автора, дозволить краще розібратися в загальнобіологічних механізмах старіння і смерті.
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