Biopolym. Cell. 1998; 14(4):286-297.
http://dx.doi.org/10.7124/bc.0004DA
Регіональна специфічність вірусної інтеграції
1Риндич А. В., 1Зубак С. В., 1Циба Л. О., 1Гулей Н., 1Лазуркевич З. В., 2Бернарді Дж.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680
  2. Інститут Жак Моно, CNRS-Університет Париж VII,
    2, Жусье, Париж, Франція, 75005

Abstract

Інтеграція ретровірусів у геном хазяїв до недавнього часу вважалася випадковою і на сьогодні не існує ясності, як впливають виявлені в місцях встановлених локальних ефектів в місцях інтеграції локальні ефекти на процес інтеграції в цілий геном. Використання композиційного підходу дало можливість встановити, що інтеграція ретровірусів відбувається у певні райони геному, які тотожні вірусним послідовностям за складом основ. Цю регіональну специфічність інтеграції доведено: 1) нашими експериментальними даними з локалізації ретровірусних послідовностей у різних композиційних ділянках геному; 2) результатами з інших лабораторій стосовно локалізації ретровірусних послідовностей у «відкритих» ділянках хроматину або/чи біля СрG-«острівців»; 3) нашим композиційним аналізом генів, розташованих по сусідству з інтегрованими вірусними послідовностями. Такий висновок має значення як для розуміння композиційної еволюції ретровірусних геномів, так і для генної терапії.
Повний текст: (PDF, українською)

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