Biopolym. Cell. 1998; 14(2):93-98.
http://dx.doi.org/10.7124/bc.0004BF
Огляди
Закономірності та механізми комбінованої дії гіпертермії і радіації на клітини пухлин
1Зінченко В. А.
  1. Український науково-дослідний інститут онкології та радіології МОЗ України
    ул. Ломоносова, 33/43, Киев, Украина, 03022

Abstract

В огляді наведено дані літератури, пов'язані з особливостями механізмів комбінованої гіпертермічної (ГТ) і променевої дії на клітини пухлин. Показано, що через різну природу поглинання енергії у клітинах після впливу іонізуючої радіації та ГТ уражаються різні молекулярні мішені: ДНК і білок відповідно, а також має місце переважаюча дія на різні фази клітинного циклу, що відіграє певну роль при сумісному застосуванні цих фізичних факторів. Розглядаються також закономірності фізіологічної реакції клітин, які обмежують деструктивну ГТ дію на клітини пухлин. Це індукція білків теплового шоку та виникнення термотолерантності. Встановлено, що інформація про термобіологічні основи дії ГТ при вивченні структурно-функціональних змін у клітинах пухлини дозволяє підвищити ступінь їхньої девіталізації.
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