Biopolym. Cell. 1998; 14(1):47-53.
http://dx.doi.org/10.7124/bc.0004B8
Структура та функції біополімерів
Фізико-хімічна природа модельних білково-нуклеїнових контактів через карбоксильну групу амінокислот: спектроскопічні дані
1Самійленко С. П., 1Коломієць І. М., 1Кондратюк І. В., 1Степанюгин А. В.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Узагальнено результати серії робіт спектроскопічного (ІЧ, УФ, ЯМР, Раман) дослідження комплексів нуклеотидних основ та їхніх численних метил- та глікозилпохідних з карбоксильною групою амінокислот, що моделюють точкові білково-нуклеїнові контакти. Встановлено специфічність взаємодії основ з двома формами карбоксильної групи – нейтральною та депротонованою. Визначено структуру досліджуваних комплексів, а також з'ясовано роль різних атомних груп основ у їхньому формуванні. Особливу увагу привертає поширеність явища перенесення протона в досліджених комплексах. Обговорюється значення отриманих результатів для розуміння елементарних механізмів білково-нуклеїнових взаємодій.
Повний текст: (PDF, англійською)

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