Biopolym. Cell. 1997; 13(3):191-196.
http://dx.doi.org/10.7124/bc.00047D
Структура та функції біополімерів
Прототропна таутомерія азотистих основ: новий погляд на стару проблему
1Говорун Д. М.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Підсумовуються результати циклу розрахунково-теоретичних досліджень фізико-хімінних зако­номірностей прототропної таутомерії нуклеотидних основ, виконаних у рамках напівемпіричного квантовохімічного методу AMI (режим оптимізації всіх структурних пара­метрів). Застосувавши нетрадиційний підхід, який грунтується на тому, що максимальна, чисельність сімейства прототропних таутомеріє основи визначається загальною кількістю протонів і вільних електронних пар атомів – акцепторів протона, вдалося встановити, що у відношенні прототропної таутомерії нуклеотидні основи є значно мобільнішими структурами (прототропна таутомерія нуклеотидних основ має молекулярно-цвітеріонний характер і відбувається за участю карбопротонів), аніж це вважалося раніше. Обговорюється біологічна, значущість отриманих результатів, які сформульовано максимально узагальнено і можуть бути розповсюджені, на думку автора, на значно ширше коло об'єктів, ніж канонічні нуклеотидні основи, їхні «складові частини» та продукти їхньої модифікації, зокрема дезамінування.
Повний текст: (PDF, українською)

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