Biopolym. Cell. 1997; 13(1):5-13.
http://dx.doi.org/10.7124/bc.00045F
Огляди
Застосування ретровірусних векторів для цілеспрямованого переносу генів у птахів
1Кайда І. В., 1Риндич А. В.
  1. Інститут молекулярної біології і генетики НАН України
    вул. Академіка Заболотного, 150, Київ, Україна, 252143

Abstract

Ретровірусні вектори успішно використовують для перенесення клонованих генів у пташиний геном шляхом інфікування ембріонів. Ефективність такого перенесення становить 0,01–0,2 % для ембріонів і 2–8 % для дорослих тварин. Розглядаються способи підвишення ефективності експресії трансгена за раху­ нок підсилення тканиноспецифічної транскрипції та включення тканиноспецифічних промоторів до складу ретровірусного вектора, а також транспортування гена у специфічні клітини-мішені за допомогою псевдотипованого вектора
Повний текст: (PDF, російською)

References

[1] Coffin JM. Structure of the retroviral genome. The molecular biology of RNA tumor virus. Eds R. Weiss et al. New York: Cold Spring Harbor Lab., 1985: 261-368.
[2] Anderson DJ, Lee P, Levine KL, Sang JS, Shah SA, Yang OO, Shank PR, Linial ML. Molecular cloning and characterization of the RNA packaging-defective retrovirus SE21Q1b. J Virol. 1992;66(1):204-16.
[3] Aronoff R, Linial M. Specificity of retroviral RNA packaging. J Virol. 1991;65(1):71-80.
[4] Aronoff R, Hajjar AM, Linial ML. Avian retroviral RNA encapsidation: reexamination of functional 5' RNA sequences and the role of nucleocapsid Cys-His motifs. J Virol. 1993;67(1):178-88.
[5] Boris-Lawrie KA, Temin HM. Recent advances in retrovirus vector technology. Curr Opin Genet Dev. 1993;3(1):102-9.
[6] Katz RA, Terry RW, Skalka AM. A conserved cis-acting sequence in the 5' leader of avian sarcoma virus RNA is required for packaging. J Virol. 1986;59(1):163-7.
[7] Knight JB, Si ZH, Stoltzfus CM. A base-paired structure in the avian sarcoma virus 5' leader is required for efficient encapsidation of RNA. J Virol. 1994;68(7):4493-502.
[8] Pugatsch T, Stacey DW. Identification of a sequence likely to be required for avian retroviral packaging. Virology. 1983;128(2):505-11.
[9] Sorge J, Ricci W, Hughes SH. cis-Acting RNA packaging locus in the 115-nucleotide direct repeat of Rous sarcoma virus. J Virol. 1983;48(3):667-75.
[10] Sakalian M, Wills JW, Vogt VM. Efficiency and selectivity of RNA packaging by Rous sarcoma virus Gag deletion mutants. J Virol. 1994;68(9):5969-81.
[11] Prasolov VS. [Retroviral vectors--an effective system for transfer and expression of foreign genes in mammalian cells]. Mol Biol (Mosk). 1989;23(2):348-55.
[12] Miller AD. Retrovirus packaging cells. Hum Gene Ther. 1990 Spring;1(1):5-14.
[13] Petropoulos CJ, Rosenberg MP, Jenkins NA, Copeland NG, Hughes SH. The chicken skeletal muscle alpha-actin promoter is tissue specific in transgenic mice. Mol Cell Biol. 1989;9(9):3785-92.
[14] Petropoulos CJ, Payne W, Salter DW, Hughes SH. Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected]. J Virol. 1992;66(6):3391-7.
[15] Bosselman R, Hsu R, Boggs T, Hu S, Bruszewski J, Ou S, et al. Germline transmission of exogenous genes in the chicken. Science.; 1989;243(4890):533–5.
[16] Bosselman RA, Hsu RY, Boggs T, Hu S, Bruszewski J, Ou S, Souza L, Kozar L, Martin F, Nicolson M, et al. Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo. J Virol. 1989;63(6):2680-9.
[17] Reddy ST, Stoker AW, Bissell MJ. Expression of Rous sarcoma virus-derived retroviral vectors in the avian blastoderm: potential as stable genetic markers. Proc Natl Acad Sci U S A. 1991;88(23):10505-9.
[18] Cosset FL, Legras C, Thomas JL, Molina RM, Chebloune Y, Faure C, Nigon VM, Verdier G. Improvement of avian leukosis virus (ALV)-based retrovirus vectors by using different cis-acting sequences from ALVs. J Virol. 1991;65(6):3388-94.
[19] Benchaibi M, Mallet F, Thoraval P, Savatier P, Xiao JH, Verdier G, Samarut J, Nigon V. Avian retroviral vectors derived from avian defective leukemia virus: role of the translational context of the inserted gene on efficiency of the vectors. Virology. 1989;169(1):15-26.
[20] Flamant F, Samarut J. Virofection: a one-step procedure for using replication-defective retrovirus vectors. Virology. 1995;211(1):234-40.
[21] Galileo DS, Gray GE, Owens GC, Majors J, Sanes JR. Neurons and glia arise from a common progenitor in chicken optic tectum: demonstration with two retroviruses and cell type-specific antibodies. Proc Natl Acad Sci U S A. 1990;87(1):458-62.
[22] Stoker AW, Hatier C, Bissell MJ. The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia. J Cell Biol. 1990;111(1):217-28.
[23] Casini T, Graf T. Bicistronic retroviral vector reveals capacity of v-erbA to induce erythroleukemia and to co-operate with v-myb. Oncogene. 1995;11(6):1019-26.
[24] Molina RM, Chebloune Y, Verdier G, Legras C. Influence of expression and cis-acting sequences from avian leukosis viruses (ALVs) on stability of (ALV)-based retrovirus vectors. C R Acad Sci III. 1995;318(5):541-51.
[25] Briskin MJ, Hsu RY, Boggs T, Schultz JA, Rishell W, Bosselman RA. Heritable retroviral transgenes are highly expressed in chickens. Proc Natl Acad Sci U S A. 1991;88(5):1736-40.
[26] Emerman M, Temin HM. Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism. Cell. 1984;39(3 Pt 2):449-67.
[27] Emerman M, Temin HM. Quantitative analysis of gene suppression in integrated retrovirus vectors. Mol Cell Biol. 1986;6(3):792-800.
[28] Southern PJ, Berg P. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J Mol Appl Genet. 1982;1(4):327-41.
[29] Ghattas IR, Sanes JR, Majors JE. The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos. Mol Cell Biol. 1991;11(12):5848-59.
[30] Dezelee P, Barnier JV, Briest'ansk? J, Geryk J, Karakoz I, Michailik AA, Nehyba J, Yatsula BA, Rynditch AV, Calothy G, et al. New case of c-src gene transduction: the generation of virus PR2257. Folia Biol (Praha). 1994;40(5):211-23.
[31] Felder MP, Eychene A, Laugier D, Marx M, Dezelee P, Calothy G. Steps and mechanisms of oncogene transduction by retroviruses. Folia Biol (Praha). 1994;40(5):225-35.
[32] Dougherty JP, Temin HM. A promoterless retroviral vector indicates that there are sequences in U3 required for 3' RNA processing. Proc Natl Acad Sci U S A. 1987;84(5):1197-201.
[33] Flamant F, Aubert D, Legrand C, Cosset FL, Samarut J. Importance of 3' non-coding sequences for efficient retrovirus-mediated gene transfer in avian cells revealed by self-inactivating vectors. J Gen Virol. 1993;74 ( Pt 1):39-46.
[34] Soriano P, Friedrich G, Lawinger P. Promoter interactions in retrovirus vectors introduced into fibroblasts and embryonic stem cells. J Virol. 1991;65(5):2314-9.
[35] Zoubak S, Rynditch A, Bernardi G. Compositional bimodality and evolution of retroviral genomes. Gene. 1992;119(2):207-13.
[36] Rynditch A, Kadi F, Geryk J, Zoubak S, Svoboda J, Bernardi G. The isopycnic, compartmentalized integration of Rous sarcoma virus sequences. Gene. 1991;106(2):165-72.
[37] Rynditch A, Zoubak S, Bernardi G. Targeted integration of viral sequences into human genome. Int. Symp. on Human Gene Therapy. Inuyama-Nagoya, 1995.
[38] Kasahara N, Dozy AM, Kan YW. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science. 1994;266(5189):1373-6.
[39] Neda H, Wu CH, Wu GY. Chemical modification of an ecotropic murine leukemia virus results in redirection of its target cell specificity. J Biol Chem. 1991;266(22):14143-6.
[40] Somia NV, Zopp? M, Verma IM. Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery. Proc Natl Acad Sci U S A. 1995;92(16):7570-4.
[41] Valsesia-Wittmann S, Drynda A, Del?age G, Aumailley M, Heard JM, Danos O, Verdier G, Cosset FL. Modifications in the binding domain of avian retrovirus envelope protein to redirect the host range of retroviral vectors. J Virol. 1994;68(7):4609-19.
[42] Cosset FL, Ronfort C, Molina RM, Flamant F, Drynda A, Benchaibi M, Valsesia S, Nigon VM, Verdier G. Packaging cells for avian leukosis virus-based vectors with various host ranges. J Virol. 1992;66(9):5671-6.
[43] Lynch CM, Miller AD. Production of high-titer helper virus-free retroviral vectors by cocultivation of packaging cells with different host ranges. J Virol. 1991;65(7):3887-90.
[44] Stoker AW, Bissell MJ. Development of avian sarcoma and leukosis virus-based vector-packaging cell lines. J Virol. 1988;62(3):1008-15.
[45] Mitrani E, Coffin J, Boedtker H, Doty P. Rous sarcoma virus is integrated but not expressed in chicken early embryonic cells. Proc Natl Acad Sci U S A. 1987;84(9):2781-4.
[46] Cosset FL, Legras C, Chebloune Y, Savatier P, Thoraval P, Thomas JL, Samarut J, Nigon VM, Verdier G. A new avian leukosis virus-based packaging cell line that uses two separate transcomplementing helper genomes. J Virol. 1990;64(3):1070-8.
[47] Cosset FL, Girod A, Flamant F, Drynda A, Ronfort C, Valsesia S, Molina RM, Faure C, Nigon VM, Verdier G. Use of helper cells with two host ranges to generate high-titer retroviral vectors. Virology. 1993;193(1):385-95.
[48] Savatier P, Bagnis C, Thoraval P, Poncet D, Belakebi M, Mallet F, Legras C, Cosset FL, Thomas JL, Chebloune Y, et al. Generation of a helper cell line for packaging avian leukosis virus-based vectors. J Virol. 1989;63(2):513-22.
[49] Hu S, Bruszewski J, Nicolson M, Tseng J, Hsu RY, Bosselman R. Generation of competent virus in the REV helper cell line C3. Virology. 1987;159(2):446-9.
[50] Dougherty JP, Wisniewski R, Yang SL, Rhode BW, Temin HM. New retrovirus helper cells with almost no nucleotide sequence homology to retrovirus vectors. J Virol. 1989;63(7):3209-12.
[51] DeLorbe WJ, Luciw PA, Goodman HM, Varmus HE, Bishop JM. Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol. 1980;36(1):50-61.
[52] Crittenden LB, Salter DW. Gene insertion: current progress and long-term goals. Avian Dis. 1986;30(1):43-6.
[53] Thomas JL, Afanassieff M, Cosset FL, Molina RM, Ronfort C, Drynda A, Legras C, Chebloune Y, Nigon VM, Verdier G. In situ expression of helper-free avian leukosis virus (ALV)-based retrovirus vectors in early chick embryos. Int J Dev Biol. 1992;36(2):215-27.
[54] Hlozanek I, Luton D, Dieterlen-Lievre F, Jaffredo T. Heart targeting of retroviral expression in avian embryos: a species-independent phenomenon. Rouxs Arch Dev Biol. 1995;204(3):212–8.
[55] Lemischka IR. Retroviral lineage studies: some principals and applications. Curr Opin Genet Dev. 1993;3(1):115-8.
[56] Souza LM, Boone TC, Murdock D, Langley K, Wypych J, Fenton D, Johnson S, Lai PH, Everett R, Hsu RY, et al. Application of recombinant DNA technologies to studies on chicken growth hormone. J Exp Zool. 1984;232(3):465-73.
[57] Crittenden LB, Salter DW, Federspiel MJ. Segregation, viral phenotype, and proviral structure of 23 avian leukosis virus inserts in the germ line of chickens. Theor Appl Genet. 1989;77(4):505-15.
[58] Yeh P, Dedieu JF, Orsini C et al. Improving adenovirus-mediated gene transfer. Int. Symp. on Human Gene Therapy Inuyama-Nagoya, 1995.
[59] Salter DW, Crittenden LB. Artificial insertion of a dominant gene for resistance to avian leukosis virus into the germ line of the chicken. Theor Appl Genet. 1989;77(4):457-61.
[60] Chebloune Y, Rulka J, Cosset FL, Valsesia S, Ronfort C, Legras C, Drynda A, Kuzmak J, Nigon VM, Verdier G. Immune response and resistance to Rous sarcoma virus challenge of chickens immunized with cell-associated glycoproteins provided with a recombinant avian leukosis virus. J Virol. 1991;65(10):5374-80.