Biopolym. Cell. 1996; 12(2):7-19.
http://dx.doi.org/10.7124/bc.00041A
Огляди
Мобільні генетичні елементи у процесах мутагенезу, рекомбінації і злоякісної трансформації клітин людини
1Лукаш Л. Л., 1Швачко Л. П., 1Костецька К. В.
  1. Інститут молекулярної біології і генетики НАН України
    вул. Академіка Заболотного, 150, Київ, Україна, 252143

Abstract

Однією з суттєвих стадій складного багатоетапного процесу злоякісної трансформації клітин є мутагенез. Про це свідчить той факт, що всі канцерогени є мутагенами. Важливою особливістю пухлин останнім часом визнана нестабільність мікросателітної ДНК. У представленому огляді на прикладі Alu-повторів з геному людини розглянуто роль мобільних генетичних елементів у виникненні спадкових і соматичних захворювань, у тому числі злоякісних новоутворень. Alu-повтори, які локалізуються у «гарячих точках» мутаційних та рекомбінаційних подій, можуть бути генетичними маркерами для оцінки нестабільності геному людини.
Повний текст: (PDF, російською)

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