Biopolym. Cell. 1995; 11(2):39-45.
Структурно-функціональний аналіз промоторної області гена алкогольоксидази метилотрофних дріжджів Hansenula polymorpha
1Витвицька О. П., 1Злочевський М. Л., 1Бебуров М. Ю.
  1. Відділення регуляторних систем клітини Інституту біохімії ім. О. В. Палладіна НАН України
    вул. Драгоманова 14/16, Львів, Україна, 79005


Досліджено вплив делецій в промоторі гена АОХ на експресію генів lac Z Escherichia coli і АОХ Н. polymorpha. Показано, що область між –403 п. о. і кодоном ATG про­ мотора АОХ абсолютно необхідна для транскрипції гена і її регуляції у метилотрофних дріжджах. Встановлено присутність у промоторі ділянок, активуючих експресію. Виявлено відмінності в регуляції експресії генів, що знаходяться під контролем промотора АОХ, у дріжджах Н. polymorpha і Saccharomyces cerevisiae.


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