Biopolym. Cell. 1995; 11(1):5-19.
Генетичні наслідки дії іонізуючого опромінення в низьких дозах на репродуктивну функцію організму миші
1Століна М. Р., 1Соломко О. П.
  1. Інститут молекулярної біології і генетики НАН України
    Київ, Україна

Abstract

В огляді розглянуто опубліковані дослідження, пов'язані із впливом малих доз іонізу­ ючого випромінення на репродуктивну функцію організму мишей різних генотипів. Ана­ліз смбріогенетичних даних, які отримано на мишах як в модельних експериментах з малими дозами радіації, так і в 30-км зоні ЧАЕС, дозволив зробити висновок про те, що генотоксичний ефект реалізується на рівні дестабілізації геному статевих та сома­тичних клітин зародків і дорослих тварин. Наслідками каріотипічної нестабільності часто є різноманітні генетичні аномалії, які ведуть до зниження репродуктивної функ­ції тварин і зростання пренатальної загибелі їх нащадків. Обговорюються перспективні напрями вивчення віддалених генетичних наслідків хронічної дії іонізуючих випромінень в малих дозах на організм ссавців.

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