Biopolym. Cell. 1994; 10(6):36-44.
http://dx.doi.org/10.7124/bc.0003C1
Сучасні аспекти генетики бактерій роду Campylobacter
1Кірік Д. Л.
  1. Інститут епідеміології та інфекційних хвороб ім. Л. В. Громашевського АМН України
    вул. Амосова, 5, Київ, Україна, 03038

Abstract

В аналкичному огляді літератури представлено сучасні дані про генетичну організацю кампілобактерій – збудників ГКІ у людини. Узагальнено відомості про молекулярні основи патогенності кампілобактерій: наявність жгутиків, ентеротоксина, головного зовнішнього мембранного білка та поверхневого білка. Гени, що кодують резистентність кампілобактерій до антибютиків (Km, Тс, Cm), клоновано i визначеноіхню нуклеотидну послідовність. Стійкість до вказаних антибютиюв має плазмідний характер, i деякі плазміди кодують більше ніж одну детермінанту. Проаналізовано механізми генетичного обміну у кампілобактерій (трансдукція, транскон'югація, транформaцiя). На сьогодні визначено розміри геному i сконструйовано пари хромосом у деяких кампілобактерій. За кордоном показано можливість використання методів молекулярної біології для практичних епідеміологічих дocлiджeнь: гель-електрофореза в електричному полі, рестрикщйно-ендонуклеазного аналізу ДНК, багатолокусного ензимного електрофореза, iмyнoблoтингa, риботипування, плазмщного аналізу i полімеразної ланцюгової реакції.
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