Biopolym. Cell. 1994; 10(1):58-66 .
http://dx.doi.org/10.7124/bc.000392
Глікобіологічні аспекти активації дихального ланцюга фагоцитів
1Тимошенко О. В., 1Черенкевич С. М.
  1. Білоруський державний університет
    просп. Фр. Скорини 4, Мінськ, Білорусь, 220050

Abstract

У стислому огляді розглянуто дані про роль білок-вуглеводних взаемодії в активації дихального вибуху фагоцитов. Відмічено, що единим глікоозильованим компонентом дихального ланцюга фагоцитов, розміщеним з зовнішного боку плазматичної мембрани, є β-субодиниця цитохрому b–245 (gp91-phox). Активащя дихального ланцюга, що виявляеться по генерації супероксидного аніон-радикала чи перекису водню, відбувається під дією ряду розчинних рослинних лектинів та при взаемодії фагоцитів з клітинами-мішенями за посередництвом єндогенних лектинів. Робиться припущення про те, що суттевим для прояву активності лектинів є їx близьюсть до функцюнально важливих гліколігандів на поверхні клітин.
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