Biopolym. Cell. 1985; 1(6):293-307.
http://dx.doi.org/10.7124/bc.000191
Огляди
Нові інгібітори біосинтезу ДНК і РНК in vitro і in vivo
1Бібілашвілі Р. Ш., 1Чіджавадзе З. Г., 2Краєвський А. А., 2Куханова М. К., 2Атражев А. М., 3Ажаєв А. В., 2Кутателадзе Т. В.
  1. Інститут експериментальної кардіології, Всесоюзного кардіологічного наукового центру АМН СРСР
    Москва, СРСР
  2. Інститут молекулярної біології АН СРСР
    Москва, СРСР
  3. Інститут фізіології АН Грузинської РСР
    Тбілісі, СРСР

Abstract

Огляд власних даних авторів щодо способів синтезу і властивостей великої кількості нових інгібіторів біосинтезу ДНК і РНК in vitro і in vivo. На індивідуальних матрицях за участі очищених ДНК- і РНК-полімераз визначено молекулярний механізм дії цих інгібіторів у реакціях полімеризації, пірофосфоролізу і гідролізу. Показано застосовність деяких інгібіторів для вивчення реплікації в культурі клітин еукаріотів, в ембріонах і ядрах клітин, а також репарації ДНК у хроматині.
Повний текст: (PDF, російською)

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