Biopolym. Cell. 1993; 9(6):35-40.
http://dx.doi.org/10.7124/bc.00037E
Structure and Function of Biopolymers
Investigation with infrared spectroscopy structure of blood albumin from healthy donors and patients with chronical renal insufficiency
1, 3Ivanov A. I., 1Korolenko E. A., 1Korolik E. V., 3Sarnatskaja V. V., 2Melestchenko L. A., 3Nikolaev V. G., 1Zhbankov R. G., 3von Appen K.
  1. B. I. Stepanov Institute of Physics, NAS of Belarus
    68, Nezavisimosti Avenue, Minsk, Republic of Belarus, 220072
  2. Institute of Bioorganic Chemistry, NAS of Belarus
    5/2, Kuprevich Str., Minsk, Republic of Belarus, 220141
  3. R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine
    45, Vasilkivska Str., Kyiv, Ukraine, 01022

Abstract

After IR and CD spectroscopy investigations there were not observed any differences between secondary structures of blood albumins from healthy donors and uremic patients. Some special features of deconvolved IR spectra of albumin from patients with short terms of hemodialysis could be a result of change in microenvironment of part from side chains of aspartic, glutamic acids and lysine in «uremi'c» albumin molecules.
Full text: (PDF, in Russian)

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