Biopolym. Cell. 1993; 9(5):34-43.
http://dx.doi.org/10.7124/bc.00036F
Structure and Function of Biopolymers
Mechanisms of the lipid peroxidation of the liver rats chromatin fractions
1Gubsky Yu. I., 1Levitsky E. L.
  1. Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine
    14, Eugene Pottier Str., Kyiv, Ukraine, 03057

Abstract

Ability for peroxidation of lipids of transcriptionally and repressed chromatin fractions of intact rat livers was shown. According to some features (the relation to inductors and inhibitors, the time's kinetics of the terminal products accumulation) chromatin's lipids peroxidation processes distinguish from ones in the liver endoplasmatic reticulum membranes. The lipid peroxidation processes are more labiled and intensived in the active chromatin fraction. This may be important for the nuclear DNA damage mechanisms. The ascorbate-dependent lipid peroxidation processes are determined only by the chromatin lipids just as NADPH-dependent ones are related to stretched nucleic acids and proteins molecules. This suggestion is proved by the fact of the rather considerable resting of NADPH-dependent lipid peroxidation after lipid extraction in the chromatin. The chromatin lipid peroxidation processes are considered as important mechanism of the nuclear genetic apparatus damages.
Full text: (PDF, in Russian)

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