Biopolym. Cell. 1989; 5(4):30-37.
http://dx.doi.org/10.7124/bc.0000D0
Structure and Function of Biopolymers
Statistical significance of the occurrence of some complex nucleotide combinations: comparison of the DNA models
1Suboch G. M., 1Sprizhitsky Yu. A.
  1. Institute of Molecular Genetics, Academy of Sciences of the USSR
    Moscow, USSR

Abstract

A scheme for modeling of the DNA chain as a sequence of the nucleotide runs of different length is presented. The advantages of such a method and range of its application are discussed. A procedure is suggested to estimate statistical significance of occurrence of some complex sequence structures in DNA by the Monte-Carlo method. It uses a bootstrap algorithm and necessitates comparatively small number of calculations. Three different models, used to derive such estimations of the frequencies of homopurine-homopyrimidine mirror repeats in the DNA of phage K and rodentia noncoding regions are compared.
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