Biopolym. Cell. 1989; 5(2):43-47.
http://dx.doi.org/10.7124/bc.0000A4
Discussions
Cloning of human α1-antitrypsin gene and possible aspects of its utilization
1Neznanov N. S., 1Makarova I. V., 2Kramerova I. A., 1Gazaryan K. G.
  1. Institute of Molecular Genetics, Academy of Sciences of the USSR
    Moscow, USSR
  2. Institute of Medical Biotechnology, Ministry of Public Health
    Moscow, USSR

Abstract

The human arantitrypsin gene has been cloned. A cDNA molecule, containing almost the whole coding sequence is isolated. Nucleotide sequence is determined for the regulatory region of α1AT gene, responsible for its expression in the liver. The possibility to use cloned genes for the gene therapy of some diseases is discussed.
Full text: (PDF, in Russian)

References

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