Detection of clinically significant gene variants in colon adenocarcinoma samples of ukrainian patients using a cancer hotspot panel

Gerashchenko, G. V.; Gulkovskyi, R. V.; Melnichuk, N. S.; Marchyshak, T. V.; Mankovska, O. S.; Bezverkhiy, A. M.; Gordiyuk, V. V.; Rosha, L. G.; Kotuza, A. S.; Kolesnik, O. A.; Tkachuk, Z. Yu.; Kashuba, V. I.; Tukalo, M. A.

doi:10.7124/bc.000AC7

Biopolym. Cell. 2024; 40(3):197-197.

http://dx.doi.org/10.7124/bc.000AC7

Chronicle and Information

Detection of clinically significant gene variants in colon adenocarcinoma samples of ukrainian patients using a cancer hotspot panel

1Gerashchenko G. V., 1Gulkovskyi R. V., 1Melnichuk N. S., 1Marchyshak T. V., 1Mankovska O. S., 1Bezverkhiy A. M., 1Gordiyuk V. V., 2Rosha L. G., 2Kotuza A. S., 3Kolesnik O. A., 1Tkachuk Z. Yu., 1Kashuba V. I., 1Tukalo M. A.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143
Feofaniya Clinical Hospital of the State Administration of Affairs
21, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143
National Cancer Institute
33/43, Yulia Zdanovska Str., Kyiv, Ukraine, 03022

Abstract

Aim. Colon cancer, one of the most common type of cancer in developed countries, was analyzed to identify clinically relevant gene variants in the samples from Ukrainian patients. Conclusions. The data demonstrate the high level identification of the clinical significant gene variants in the colon cancer samples by the CHP. Further confirmation on a larger number of samples and deeper analysis of clinical significant gene variants as potential clinical relevant mutations by other approaches would be beneficial.

Keywords: NGS, clinically significant gene variants, Cancer Hotspot panel, colon cancer

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