Biopolym. Cell. 2023; 39(1):42-53.
http://dx.doi.org/10.7124/bc.000A84
Bioorganic Chemistry
New polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents
1Lozynskyi A. V., 1Konechnyi Y. T., 1Roman O. M., 1Horishny V. Ya., 2Sabadakh O. P., 1Pasichnyk S. M., 3Konechna R. T., 2Shupeniuk V. I., 2Taras T. M., 1, 4Lesyk R. B.
  1. Danylo Halytsky Lviv National Medical University
    69, Pekarska Str., Lviv, Ukraine, 79010
  2. Vasyl Stefanyk Precarpathian National University
    57, Shevchenko Str., Ivano-Frankivsk, Ukraine, 76018
  3. Lviv Polytechnic National University
    12, Stepan Bandera Str., Lviv, Ukraine, 79013
  4. University of Information Technology and Management in Rzeszow
    2, Sucharskiego Str., Rzeszow, Poland, 35-225

Abstract

Aim. Synthesis and study of new polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents. Methods. Organic synthesis, NMR and LC-MS spectroscopy, agar diffusion and broth microdilution methods. Results. A series of anthraquinonehydrazone derivatives are synthesized using the reaction of 2-(morpholinodiazenyl)anthracene-9,10-dione with methylene active compounds in the acetic acid medium. The screening of antimicrobial activity identified the compounds with significant effects against the tested microorganisms with MIC value <186.9 μM. Compounds 5 and 11 with MIC <93.5 μM are effective against yeast fungi whereas compound 5 with MIC <186.9 μM is effective against P.putida, which is multidrug resistant to antibiotics. Conclusions. The obtained hydrazino-anthraquinone derivatives constitute an interesting background for the design of new synthetic agents with antimicrobial activity.
Keywords: anthraquinones, methylene active compounds, 4-thiazolidinones, antimicrobial activity
Full text: (PDF, in English)

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