Biopolym. Cell. 2013; 29(4):348-353.
http://dx.doi.org/10.7124/bc.000829
Reviews
Development of the system for gene therapy of AIDS on the basis of antisense RNAs
1Shved A. D., 1Kukharenko O. P.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Based on adeno-associated virus derived plasmid construct that are able to synthesize in cells antisense RNAs directed against key genes of HIV. Gematopoietic human cells carrying the created structure, acquired resistance to HIV infection, as evidenced by the reduction in infectious titer of HIV in cell culture. The resulting system of intracellular resistance to retrovirus can be seen as a model of gene therapy of AIDS.
Keywords: HIV-AIDS, adeno-associated virus, antisense RNAs, gene therapy, gematopoietic human cells
Full text: (PDF, in English) (PDF, in Ukrainian)

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