Biopolym. Cell. 2008; 24(5):393-398.
http://dx.doi.org/10.7124/bc.0007B7
Structure and Function of Biopolymers
Dynamics of heat shock proteins quantity in rats’ gastric mucosa lysates upon chronic atrophic gastritis development
1, 2Mandryk S. Ya., 1Gaida L. N., 2Kapustian L. M., 2Tykhonkova I. O., 1Drobinska O. V., 2Sidorik L. L., 1Ostapchenko L. I.
  1. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01601
  2. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

The levels of Hsp60, Hsp70 and Hsp90 in rats’ gastric mucosa cells lysates upon the development of experimental chronic atrophic gastritis (CAG) were investigated by the immunoblot-analysis. The quantities of Hsp60 and Hsp70 at the early (the first two weeks) and late (the 5–6th weeks) stages of disease progression were reliably higher in comparison with normal mucosa. It was also observed an increase in Hsp90 expression at the end of the first week of CAG. The increase in Hsp expression in gastric mucosa was shown upon activation of apoptosis, generation of reactive oxygen species, and gastric atrophy development.
Keywords: atrophic gastritis, atrophy, heat shock proteins
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