Biopolym. Cell. 2005; 21(6):463-472.
Reviews
Methyltransferases of plants
- Institute of Plant Physiology and Genetics, NAS of Ukraine
31/17, Vasylkivska, Kyiv, Ukraine, 03022
Abstract
In the review the current data on the plant cytosine-C5-DNA-methyltransferases (methyltransferase) are summarized. Three different classes of these enzymes – Dnmt1/MET1, Dnmt3 and CMT are discribed. The proposed function, dealing with maintenance and de novo methylation of cytosine residues in symmetric and asymmetric motifs of DNA, is under discussion.
Keywords: methylation, cytosine, methyltransferase
Full text: (PDF, in Russian)
References
[1]
Finnegan EJ, Genger RK, Peacock WJ, Dennis ES. DNA METHYLATION IN PLANTS. Annu Rev Plant Physiol Plant Mol Biol. 1998;49:223-247.
[2]
Ng HH, Bird A. DNA methylation and chromatin modification. Curr Opin Genet Dev. 1999;9(2):158-63.
[5]
Cao X, Jacobsen SE. Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. Curr Biol. 2002;12(13):1138-44.
[6]
Papa CM, Springer NM, Muszynski MG, Meeley R, Kaeppler SM. Maize chromomethylase Zea methyltransferase2 is required for CpNpG methylation. Plant Cell. 2001;13(8):1919-28.
[7]
Finnegan EJ, Dennis ES. Isolation and identification by sequence homology of a putative cytosine methyltransferase from Arabidopsis thaliana. Nucleic Acids Res. 1993;21(10):2383-8.
[8]
Wada Y, Ohya H, Yamaguchi Y, Koizumi N, Sano H. Preferential de novo methylation of cytosine residues in non-CpG sequences by a domains rearranged DNA methyltransferase from tobacco plants. J Biol Chem. 2003;278(43):42386-93.
[9]
Genger RK, Kovac KA, Dennis ES, Peacock WJ, Finnegan EJ. Multiple DNA methyltransferase genes in Arabidopsis thaliana. Plant Mol Biol. 1999;41(2):269-78.
[10]
Bernacchia G, Primo A, Giorgetti L, Pitto L, Cella R. Carrot DNA-methyltransferase is encoded by two classes of genes with differing patterns of expression. Plant J. 1998;13(3):317-29.
[11]
Pradhan S, Cummings M, Roberts RJ, Adams RL. Isolation, characterization and baculovirus-mediated expression of the cDNA encoding cytosine DNA methyltransferase from Pisum sativum. Nucleic Acids Res. 1998;26(5):1214-22.
[12]
Steward N, Kusano T, Sano H. Expression of ZmMET1, a gene encoding a DNA methyltransferase from maize, is associated not only with DNA replication in actively proliferating cells, but also with altered DNA methylation status in cold-stressed quiescent cells. Nucleic Acids Res. 2000;28(17):3250-9.
[13]
Cao X, Springer NM, Muszynski MG, Phillips RL, Kaeppler S, Jacobsen SE. Conserved plant genes with similarity to mammalian de novo DNA methyltransferases. Proc Natl Acad Sci U S A. 2000;97(9):4979-84.
[15]
Sethmann S, Ceglowski P, Willert J, Iwanicka-Nowicka R, Trautner TA, Walter J. M.(phi)BssHII, a novel cytosine-C5-DNA-methyltransferase with target-recognizing domains at separated locations of the enzyme. EMBO J. 1999;18(12):3502-8.
[16]
Mi S, Roberts RJ. How M.MspI and M.HpaII decide which base to methylate. Nucleic Acids Res. 1992;20(18):4811-6.
[17]
Yen RW, Vertino PM, Nelkin BD, Yu JJ, el-Deiry W, Cumaraswamy A, Lennon GG, Trask BJ, Celano P, Baylin SB. Isolation and characterization of the cDNA encoding human DNA methyltransferase. Nucleic Acids Res. 1992;20(9):2287-91.
[18]
Bestor T, Laudano A, Mattaliano R, Ingram V. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988;203(4):971-83.
[19]
Teerawanichpan P, Chandrasekharan MB, Jiang Y, Narangajavana J, Hall TC. Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus. Planta. 2004;218(3):337-49.
[20]
Wada Y, Miyamoto K, Kusano T, Sano H. Association between up-regulation of stress-responsive genes and hypomethylation of genomic DNA in tobacco plants. Mol Genet Genomics. 2004;271(6):658-66.
[21]
Leonhardt H, Page AW, Weier HU, Bestor TH. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell. 1992;71(5):865-73.
[22]
Robertson KD, Jones PA. DNA methylation: past, present and future directions. Carcinogenesis. 2000;21(3):461-7.
[23]
Milutinovic S, Zhuang Q, Niveleau A, Szyf M. Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes. J Biol Chem. 2003;278(17):14985-95.
[24]
Vertino PM, Sekowski JA, Coll JM, Applegren N, Han S, Hickey RJ, Malkas LH. DNMT1 is a component of a multiprotein DNA replication complex. Cell Cycle. 2002;1(6):416-23.
[25]
Okuwaki M, Verreault A. Maintenance DNA methylation of nucleosome core particles. J Biol Chem. 2004;279(4):2904-12.
[26]
Ronemus MJ, Galbiati M, Ticknor C, Chen J, Dellaporta SL. Demethylation-induced developmental pleiotropy in Arabidopsis. Science. 1996;273(5275):654-7.
[27]
Finnegan EJ, Peacock WJ, Dennis ES. Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development. Proc Natl Acad Sci U S A. 1996;93(16):8449-54.
[28]
Kankel MW, Ramsey DE, Stokes TL, Flowers SK, Haag JR, Jeddeloh JA, Riddle NC, Verbsky ML, Richards EJ. Arabidopsis MET1 cytosine methyltransferase mutants. Genetics. 2003;163(3):1109-22.
[29]
Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992;69(6):915-26.
[30]
Bartee L, Bender J. Two Arabidopsis methylation-deficiency mutations confer only partial effects on a methylated endogenous gene family. Nucleic Acids Res. 2001;29(10):2127-34.
[31]
Henikoff S, Comai L. A DNA methyltransferase homolog with a chromodomain exists in multiple polymorphic forms in Arabidopsis. Genetics. 1998;149(1):307-18.
[32]
Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen SE. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Science. 2001;292(5524):2077-80.
[33]
Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SI. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science. 2001;292(5514):110-3.
[34]
Jackson JP, Lindroth AM, Cao X, Jacobsen SE. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature. 2002;416(6880):556-60.
[35]
Giannino D, Mele G, Cozza R, Bruno L, Testone G, Ticconi C, Frugis G, Bitonti MB, Innocenti AM, Mariotti D. Isolation and characterization of a maintenance DNA-methyltransferase gene from peach (Prunus persica [L.] Batsch): transcript localization in vegetative and reproductive meristems of triple buds. J Exp Bot. 2003;54(393):2623-33.
[36]
Tariq M, Saze H, Probst AV, Lichota J, Habu Y, Paszkowski J. Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin. Proc Natl Acad Sci U S A. 2003;100(15):8823-7.
[37]
Kato M, Miura A, Bender J, Jacobsen SE, Kakutani T. Role of CG and non-CG methylation in immobilization of transposons in Arabidopsis. Curr Biol. 2003;13(5):421-6.
[38]
Cao X, Aufsatz W, Zilberman D, Mette MF, Huang MS, Matzke M, Jacobsen SE. Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation. Curr Biol. 2003;13(24):2212-7.
[40]
Hamilton A, Voinnet O, Chappell L, Baulcombe D. Two classes of short interfering RNA in RNA silencing. EMBO J. 2002;21(17):4671-9.