Biopolym. Cell. 2005; 21(1):64-69.
Molecular Biomedicine
Nonlinear kinetics of tumor volumes and spatial chaos of sarcoma 45 cell shapes after the treatment by mechanically modified doxorubicin, 40 MHz irradiation and their combination
1Zinchenko V. A., 2Orel V. E., 3Belov Yu. A., 2Dzyatkovskaya N. M., 2Danko M. I., 2Romanov A. V., 2, 3Morozov O. B., 4Pridatko O. Yu.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Institute of Oncology of Academy of Medical Sciences of of Ukraine
    Street. University, 33/43, Kiev, Ukraine, 03022
  3. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033
  4. R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine
    45, Vasilkivska Str., Kyiv, Ukraine, 01022


The characteristic features of malignant tumors may be the pecu­liarities of the nonlinear growth dynamics and atypical cell shapes, which can be qualitatively estimated on the basis of a deterministic chaos conception. The comparative study of nonlinear kinetics of tumor volumes change, spatial chaos of cell shapes and cytological changes of cells in animals with sarcoma-45 under the influence of 40 MHz electromagnetic irradiation (El), anticancer anthracycline antibiotic officinal doxorubicin (DR) and mechanochemically ac­tivated (MA) DR and their combination was undertaken. The kinetics of sarcoma-45 tumor volumes change in control animals (without any treatment) was the most nonlinear, while after the combined action of EI and MA DR the nonlinearity was minimal. The shapes of tumor cells in control animals as well as of the cells mostly affected by MA DR and EI action have the greatest spatial chaos. Possibly it is a result of changes in deterministic molecular chaos in tumor cells under chemical treatment with MA DR and EI.
Keywords: cells of sarcoma-45, doxorubicin, electromagnetic irradiation, chaos


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