Biopolym. Cell. 2004; 20(5):435-439.
http://dx.doi.org/10.7124/bc.0006C7
Bioorganic Chemistry
The glycosilic analogues of 6-aza-cytidine: synthesis and antiviral activity
1Alexeeva I. V., 1Palchikovskaya L. I., 2Nosach L. N., 2Usenko L. S., 2Zhovnovataya V. L., 2Dyachenko N. S.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
    154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

A number of N1-glycopyranosyl and N1-glycofuranosyl 6-azacytidine analogues were synthesized by one-step «silylic condensation» method. Antiadenovirus activity of these compounds in comparison with parent 6-azacytidine was studied. Preserving D-ribofuranosylic fragment in the analog molecule has been shown necessary for this biological activity. Commutation of this sugar moiety into D-xylose, D-glucose, L-arabinose or even commutation of D-ribofuranosylic fragment into ribopyrano ring in 6-azacytidine molecule leads to the loss in antiadenovirus activity.
Full text: (PDF, in Ukrainian)

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