Biopolym. Cell. 2002; 18(6):540-546.
http://dx.doi.org/10.7124/bc.000633
Bioorganic Chemistry
Interaction of cyanine dyes with nucleic acids. Spectral-luminescent properties of pyrylium and pyridinium mono/trimethincyanines
1Kovalska V. B., 2Valyukh I. V., 1Kostenko O. M., 1Dmitrieva S. Yu., 3Tolmachov O. I., 1Yarmoluk S. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033
  3. Institute of organic chemistry NAS of Ukraine
    5, Murmanska Str., Kyiv, Ukraine, 02660

Abstract

The spectral-luminescent properties of series of pyrylium and pyridinium mono- and trimethincyanines as possible fluorescent dyes for the nucleic acids (NA) detection and labeling were studied. We propose 3,6-methUendioxy-benzothiazolomonomethinepyridocy-anine MDO40 for using in homogeneous assay, as well as for the construction of otigonuleotides-based «light-up probes».
Full text: (PDF, in Ukrainian)

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