Study of iodination mechanism of 5\'-O-prolecled pyrimidine Hucleosides in Arbuzov reaction conditions

Kostina, V. G.; Shalamay, A. S.; Usenko, L. S.; Gladkaya, V. A.

doi:10.7124/bc.0004D5

Biopolym. Cell. 1998; 14(3):246-251.

http://dx.doi.org/10.7124/bc.0004D5

Methods

Study of iodination mechanism of 5'-O-prolecled pyrimidine Hucleosides in Arbuzov reaction conditions

1Kostina V. G., 1Shalamay A. S., 1Usenko L. S., 1Gladkaya V. A.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Tlw mechaflism of iodination of C2- and C3-atoms of ribofuranose In pyrimidine nudeosides in conditions of Arbuzov reaction have been studied. Intermediate 2'- and 3''-quaziphosphonium salts where, shown, to be involved in further intramolecular nudeophilic reactions, the resulting 2',3'-diiododerivative being deiodinated and transformed into correspondent 2',3'-didehydro-2'-3'-dideoxynuc-leosides.

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