Biopolym. Cell. 1997; 13(4):285-290.
http://dx.doi.org/10.7124/bc.00048C
Structure and Function of Biopolymers
N4-deriva tives of 6-azacytidine: synthesis and biological activity
1Alexeeva I. V., 1Palchikovskaya L. I., 1Shalamay A. S., 1Tarnavsky S. S., 2Nosach L. M., 2Zhiovnovataya V. I., 2Dyachenko N. S.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
    154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

Different methods of the synthesis of N4-derivatives of 6-azacytidine in conditions of simplified "sililic condensation" methods were investigated. Their antivirus activity with respect to the serotype 2 adenovirus in the culture of Hep-2 cells was studied. Primary specific activity of the compounds obtained was defined. Correlation between chemical structure of the new 6-azacytidine derivatives and its biological properties is discussed.
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