Biopolym. Cell. 1995; 11(6):108-112.
http://dx.doi.org/10.7124/bc.00040C
TTGA-tandem repeats allelic polymorphism of dystrophin gene among healthy volunteers from different regions of Ukraine and in DMD-families
1Ekshiyan A. Yu., 1Livshits L. A., 1Kravchenko S. A., 1Melnik V. W., 1Musienko S. I., 1Grishko V. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

The analysis or polymorphisms TTGA-tandem repeals in 3'-untranslated region of dystrophin gene was performed among healthy population of Kiev and Lugansk regions and in 47 HMD-families from different regions of Ukraine as well. The distribution of the TTGA-tandem repeats allelic variants was obtained. Unknown allelic variant of the TTGA-tandem repeats (presumable three TTGA-unils) was found. This system was diagnostically informatived for 15 DMD-families
Full text: (PDF, in Russian)

References

[1] Cavalli-Sforza LL. Opinion: how can one study individual variation for 3 billion nucleotides of the human genome? Am J Hum Genet. 1990;46(4):649-51.
[2] Prior TW, Friedman KJ, Silverman LM. RFLP for HindIII at the Duchenne muscular dystrophy gene. Nucleic Acids Res. 1989;17(6):2370.
[3] Bakker E, Bonten EJ, De Lange LF, Veenema H, Majoor-Krakauer D, Hofker MH, Van Ommen GJ, Pearson PL. DNA probe analysis for carrier detection and prenatal diagnosis of Duchenne muscular dystrophy: a standard diagnostic procedure. J Med Genet. 1986;23(6):573-80.
[4] Roberts RG, Montandon AJ, Bobrow M, Bentley DR. Detection of novel genetic markers by mismatch analysis. Nucleic Acids Res. 1989;17(15):5961-71.
[5] Chakraborty R, Zhong Y, de Andrade M, Clemens PR, Fenwick RG, Caskey CT. Linkage disequilibria among (CA)n polymorphisms in the human dystrophin gene and their implications in carrier detection and prenatal diagnosis in Duchenne and Becker muscular dystrophies. Genomics. 1994;21(3):567-70.
[6] Grishko V. I., Malarchuk S. G., Livshits L. A. Polymorphism of pERT locus of dystrophin gene in families with high risk of muscular Duchenne dystrophy and within healthy women from Ukraine. Biopolym. Cell. 1993; 9(4):105-108
[7] Wehnert M, Herrmann FH, Metzke H, Thiele H, Vogel G, Kuhnert W, Ebener U, Wulff K. Initial results of genetic carrier diagnosis in risk pedigrees with hemophilia A and B in East Germany. Z Gesamte Inn Med. 1988;43(16):441-4.
[8] Zhivotovsky LA Statistical methods for analysis of gene frequencies in natural populations. Theoretical population genetics. VINITI, 1983: 76-104. (Results of Science and Technology. Ser. General genetics; Vol. 8)
[9] Livshits LA, Grishko VI, Maliarchuk SG, Kravchenko SA. The polymorphism of the tandem repeats in the dystrophin gene in the Ukrainian population. Tsitol Genet. 1994;28(3):79-85.