Biopolym. Cell. 1995; 11(1):5-19.
The genetical effect of chronical ionizing irradiation in low doses on mice reproductive function
- Institute of Molecular Biology and Genetics, NAS of Ukraine
Kiev, Ukraine
Abstract
Publications dealing with the effect of low-dosed irradiation on the reproductive function of mice are briefly reviewed. The analysis of the embryogenetical data obtained on mice in model experiments with low doses of radiation, as well as in 30-km Chernobyl zone, made us to conclude that the resulting genetical effect of these doses is the instability of germ and somatic cells of embryos and adults. Different genetical abnormalities leading to the inhibition of reproductive function and the increasing of progeny death, are the result of induced karyotype instability. The discussion emphasizes on the new directions of such investigations.
Full text: (PDF, in Ukrainian)
References
[2]
Sankaranarayanan K. Ionizing radiation and genetic risks. I. Epidemiological, population genetic, biochemical and molecular aspects of Mendelian diseases. Mutat Res. 1991;258(1):3-49.
[3]
Sankaranarayanan K. Estimates of genetic risks of exposure to ionising radiation and their use in radiation protection: The 1992 status. J Radiol Prot. 1992;12(3):129–36.
[4]
Shelby MD, Bishop JB, Mason JM, Tindall KR. Fertility, reproduction, and genetic disease: studies on the mutagenic effects of environmental agents on mammalian germ cells. Environ Health Perspect. 1993;100:283-91.
[6]
U. S. Congress. Office of Technology Assainment. Technologies for detecting heritable mutations in Human beings. Report no. OTA-H-298. U. S. Goverment Printing Office. Washington : DC, 1986.
[7]
Ehling UH. Germ-cell mutations in mice: standards for protecting the human genome. Mutat Res. 1989;212(1):43-53.
[8]
Staats J. Standardized nomenclature for inbred strains of mice: seventh listing for the International Committee on Standardized Genetic Nomenclature for Mice. Cancer Res. 1980;40(7):2083-128.
[9]
Robl JM, Lohse-Heideman JK, First NL. Strain differences in early mouse embryo development in vitro: role of the nucleus. J Exp Zool. 1988;247(3):251-6.
[10]
Oleson FB. Overview of in vitro mammalian testing systems. Environ and Mol Mutagenes. 1989; (Suppl. 14):146-51.
[11]
BARC Highlights. Transmissible genetic damage following paternal post-meiotic exposure of Swiss mice. Bombay, 1989: 178-80.
[12]
Selby PV, Generoso WM, Raymer GD. et at. Ethylnitrosourea (ENU) exposure of early mouse zygotes induces a high frequency of dominant skeletal mutations. Environ, Mol Mutagen. 1991; 17(Suppl. 19):67-9.
[13]
Russell LB, Bangham JW. The paternal genome in mouse zygotes is less sensitive to ENU mutagenesis than the maternal genome. Mutat Res. 1991;248(1):203-9.
[14]
Shevchenko VA, Pomerantseva M. D. Genetic effects of ionizing radiation. Moscow: Nauka, 1985. 280 p.
[15]
Onishi A, Mikami H. Paternal Heterosis for Reproductive Traits in Mice. Anim Sci J. 1990;61(10):897–902.
[16]
Brewen JG, Payne HS, Jones KP, Preston RJ. Studies on chemically induced dominant lethality. I. The cytogenetic basis of MMS-induced dominant lethality in post-meiotic male germ cells. Mutat Res. 1975;33(2-3):239-50.
[17]
Katoh MA, Cain KT, Hughes LA, Foxworth LB, Bishop JB, Generoso WM. Female-specific dominant lethal effects in mice. Mutat Res. 1990;230(2):205-17.
[18]
Bishop JB, Shelby MD. Mammalian heritable effects research in the national toxicology program. Bundury report 34: Biology of mammalian germ cell mutagenesis. New York : Cold Spring Harbor, 1990: 425-435.
[19]
Russell LB, Russell WL, Rinchik EM. et al. Factors affecting the nature of induced mutation. New York : Cold Spring Harbor, 1990: 271-289.
[20]
O W, Baker TG. Initiation and control of meiosis in hamster gonads in vitro. J Reprod Fertil. 1976;48(2):399-401.
[21]
Almond DG, Singh RP. Development of the Sertoli cell in the fetal mouse. Acta Anat (Basel). 1980;106(2):276-80.
[22]
Bridges BA. Aspects of germ cells relevant to mutagenic risk evaluation: some concluding remarcs. New York : Conf. Cold Spring Harb. Plainview, 1990: 451-4.
[23]
Veneroso WM, Rutledge JC, Aronson F. Developmental anomalies: Mutational consequence of mouse zygote exposure. New York : Conf. Cold Spring Harb. Plainview, 1990-P. 311-319.
[24]
Generoso WM, Rutledge JC, Cain KT, Hughes LA, Braden PW. Exposure of female mice to ethylene oxide within hours after mating leads to fetal malformation and death. Mutat Res. 1987;176(2):269-74.
[25]
Generoso WM, Rutledge JC, Cain KT, Hughes LA, Downing DJ. Mutagen-induced fetal anomalies and death following treatment of females within hours after mating. Mutat Res. 1988;199(1):175-81.
[26]
Dandekar PV, Glass RH. Development of mouse embryos in vitro is affected by strain and culture medium. Gamete Res. 1987;17(4):279-85.
[27]
Chatot CL, Lewis JL, Torres I, Ziomek CA. Development of 1-cell embryos from different strains of mice in CZB medium. Biol Reprod. 1990;42(3):432-40.
[28]
Goddard MJ, Pratt HP. Control of events during early cleavage of the mouse embryo: an analysis of the '2-cell block'. J Embryol Exp Morphol. 1983;73:111-33.
[29]
Moore MM, Fuscoe JC, Hozier JC. et al. Spectrum of genetic damage defected by mammalian cell mutation assays. Environ Mol Mutagenes. 1991; 17(Suppl. N 19):53.
[30]
Prosser JS, Lloyd DC, Edwards AA. A comparison of chromosomal and micronuclear methods for radiation accident dosimetry. Radiat. Prot. Theory and Praci.: Proc. 4th Int. Symp. Soc. Radiol. Prot. Bristol; New York, 1989: 133-6.
[31]
Bender MA, Awa AA, Brooks AL, Evans HJ, Groer PG, Littlefield LG, Pereira C, Preston RJ, Wachholz BW. Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutat Res. 1988;196(2):103-59. Review.
[32]
Macklis RM, Beresford B. Radiation hormesis. J Nucl Med. 1991;32(2):350-9.
[33]
Oftedal P. A holistic view of low-level radiation effects in biological systems. Can J Phys. 1990;68(9):974–8.
[34]
Kuzin AM. The action of atomic radiation in low doses on the biota. Radiobiologiia. 1991;31(2):175-9.
[35]
Spitkovskiĭ DM, Lunga IN, Shishkin SS, Kovalev LI, Talyzina TA. Genetic effects of the action of small doses of ionizing radiation: problems of cellular response and approaches to their study. Vestn Ross Akad Med Nauk. 1992;(4):39-46.
[36]
Dubinina L. G., Kurashova Z. I., Volkova I. V., Dubinin N. P. Low doses of ionizing radiation and inducible repair system. Dokl Akad Nauk SSSR. 1990; 311(2):481-3.
[37]
Dubinin I. P. Action of small doses of pollution of the biosphere and mutagenic factors. Usp Sovrem Biol. 1990; 109(3):323-38.
[38]
Filippovich IV. The phenomenon of adaptive response in radiobiology. Radiobiologiia. 1991;31(6):803-14.
[39]
Sikov M. R. Hazards and risks from prenatal irradiation: Empihasis on internal radionuclide exposures. Radiat Prot Dosim. 1992; 41(2-4):265-72.
[40]
Harrison JD, Morgan A, Haines JW, Stather JW. Fetal uptake of plutonium and polonium in animals and estimates of doses to humans. Int J Radiat Biol. 1991;60(3):555-9.
[41]
Morgan A, Harrison JD, Stather JW. Doses to the human fetus from plutonium intakes during pregnancy. Radiat Prot Bull. 1990; (114):10-4.
[42]
Tao Feng, Zhu Shoupeng. The effect of pregnancy and lactation on accumulation of Pm-147 in mice. Chin J Radiol Med Prot. 1991; 11(4):242-5.
[43]
Mason TM, Lord BI, Molineux G, Humphreys ER. Alpha-irradiation of haemopoietic tissue in pre- and postnatal mice: 2. Effects of mid-term contamination with 239Pu in utero. Int J Radiat Biol. 1992;61(3):393-403.
[44]
Mason TM, Humphreys ER, Lord BI. Alpha-particle irradiation of haemopoietic tissue in pre- and postnatal mice. 1: Distribution of plutonium-239 after mid-term contamination. Int J Radiat Biol. 1991;59(2):467-78.
[45]
Van Der Heuvel R., Vander P. F. et al. 241 Am distribution and retention in pregnant mice, in their offspring and in non-pregnant mice. Radiat Prot Dosim. 1992; 41(2-4):137-42.
[46]
Lardon F., Van Der Heuvel R., Schoeters G. et al. Effects of 241 Am on haemopoietic and stromal stem cells in mice after foetal and perinatal radioactive contamination. Belg J Zool. 1990; 120(1):77-8.
[47]
Taylor DM, Bligh PH. The transfer of Ca-45, Sr-85 and Ba-140 from mother to newborn in rats. Radiat Prot Dosim. 1992; 41(2-4):143-5.
[48]
Sikov MR, Meznarich HK, Traub RJ. Comparison of placental transfer and localization of caesium, strontium and iodine in experimental animals and women. Int J Radiat Biol. 1991;60(3):553-5.
[49]
Devi PU, Hande MP. Effect of low dose of 70 kVp X-rays on the intrauterine development of mice. Experientia. 1990;46(5):511-3.
[50]
Müller WU, Streffer C. Lethal and teratogenic effects after exposure to X-rays at various times of early murine gestation. Teratology. 1990;42(6):643-50.
[51]
Bocharova LP, Vasilenko OV, Strel'nikova NK. Dependence of the reproductive function of mice from local irradiation dose, conducted at different times before and after conception. Radiation Hygiene. L., 1989: 75-81.
[52]
Jung T, Streffer C. Association of protein phosphorylation and mitosis in normally dividing and X-irradiated 2-cell mouse embryos. J Reprod Fert. Abst. Ser. 1989;(3):18-21.
[53]
Selby PB, Lee SS, Kelly EM, Bangham JW, Raymer GD, Hunsicker PR. Specific-locus experiments show that female mice exposed near the time of birth to low-LET ionizing radiation exhibit both a low mutational response and a dose-rate effect. Mutat Res. 1991;249(2):351-67.
[54]
Satow Y, Hori H, Lee JY, Ohtaki M, Sawada S, Nakamura N, Okada S. Effect of tritiated water on female germ cells: mouse oocyte killing and RBE. Int J Radiat Biol. 1989;56(3):293-9.
[55]
Griffin CS, Tease C, Fisher G. The effect of low-dose X-irradiation on numerical and structural chromosome anomaly induction in mouse immature oocytes. Mutat Res. 1990;231(2):137-42.
[56]
Cattanach BM, Rasberry C, Beechly C. Factors affecting mutation induction by X-rays in the spermatogonial stem cells of mice of strain 101. H. Biol. mammal. germ cell mutagenesis. New York: Conf. Cold Spring Harbor, 1990: 209-218.
[57]
Straume T, Kwan TC, Goldstein LS, Dobson RL. Measurement of neutron-induced genetic damage in mouse immature oocytes. Mutat Res. 1991;248(1):123-33.
[58]
Boerjan ML, Saris LA. The effects of spermatozoal irradiation with X-rays on chromosome abnormalities and on development of mouse zygotes after delayed fertilization. Mutat Res. 1991;256(1):49-57.
[59]
Tease C, Fisher G. The influence of maternal age on radiation-induced chromosome aberrations in mouse oocytes. Mutat Res. 1991;262(1):57-62.
[60]
Backer LC, Sontag MR, Allen JW. Stage-specific damage to synaptonemal complexes and metaphase chromosomes induced by X rays in male mouse germ cells. Radiat Res. 1991;125(2):187-96.
[61]
Cai L, Wang M, Wang X. Comparison of radiation-induced chromosome aberrations in germ cells of mice. Chin J Radiol Med Prot. 1990; 10(6): 379-82.
[62]
de Boer P, van der Hoeven FA. Chromosome damage and non-disjunction measured at the first cleavage division in normal and chromosomally mutant female mice irradiated at the diakinesis stage of female meiosis. Mutat Res. 1991;248(1):155-62.
[63]
Kalina I, Ondruššeková A, Konečná H. Frequency of chromosomal non-disjunction after low-dose irradiation in mice. Mutat Res. 1989;216(5):303.
[64]
Wiley LM. What is the radiosensitive target of mammalian gametes and embryos at low doses of radiation? Biol, mammal, germ cell mutagenesis. New York: Conf. Cold Spring Harbor, 1990: 299-310.
[65]
Warner P, Wiley LM, Oudiz DJ, Overstreet JW, Raabe OG. Paternally inherited effects of gamma radiation on mouse preimplantation development detected by the chimera assay. Radiat Res. 1991;128(1):48-58.
[66]
Straume T, Raabe OG, Walsh KJ, Wiley LM. Inherited effects from irradiated mouse immature oocytes detected in aggregation embryo chimeras. Mutat Res. 1993;287(2):243-51.
[67]
Matsuda Y, Seki N, Utsugi-Takeuchi T, Tobari I. Changes in X-ray sensitivity of mouse eggs from fertilization to the early pronuclear stage, and their repair capacity. Int J Radiat Biol. 1989;55(2):233-56.
[68]
Jacquet P, Grinfeld S. Influence of some methodological factors on the radiosensitivity of the mouse zygote. Teratology. 1990;42(4):453-62.
[69]
Nénot JC. Overview of the radiological accidents in the world, updated December 1989. Int J Radiat Biol. 1990;57(6):1073-85.
[70]
Mole RH. Human in utero development. Applications to the radiological protection]. J Radiol. 1991;72(12):689-96.
[71]
Treatment of extremely low doses. Radiol Prot Bull. 1990;(109):3-4.
[72]
Neel JV, Schull WJ, Awa AA, Satoh C, Kato H, Otake M, Yoshimoto Y. The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans. Am J Hum Genet. 1990;46(6):1053-72.
[73]
Oftedal P. The Chernobyl accident: Fallout and possible effects in Norwau. Low dose radiation. London : Tylor and Francis, 1989: 143-53.
[74]
Ramayya D K., Pomerantseva M. D., Shevchenko V. A. Genetic consequences of the Chernobyl accident in house mice. Evolution. and genet. mammal research: Proc. of reports. Proc. . meetting. Vladivostok, 1990. Part 2: 143-145.
[75]
Riabokon NI. Comparative analysis of (radioactive contamination on populations of two species of rodents. VI Congress of Bel. Ogiso: Proc. Dokl. Minsk, 1992: 16.
[76]
Pomerantseva MD, Testov BV, Ramaĭia LK, Shevchenko VA, Chekhovich AV. Genetic disorders in laboratory mice exposed in the area of the Chernobyl Atomic Electric Power Station. Tsitol Genet. 1990;24(4):46-50. Russian.
[77]
Pomerantseva MD, Chekhovich AV, Ramaiĭa LK, Shevchenko VA, Shaks AI, Lobaneva NV. Genetic effects in mice exposed to the 10-km area around the Chernobyl Atomic Energy Station. Genetika. 1990;26(10):1870-5. Russian.
[78]
Chekhovich AV, Pomerantseva MD, Ramaĭia LK, Shevchenko VA. Genetic disorders in laboratory mice, exposed in the region of the Chernobyl Atomic Power Plant four years after the accident. Genetika. 1993;29(2):312-22.
[79]
Charles Darwin Origin of Species. Moscow: Izd Lepkovekogo Yu, 1907. 430 p.
[80]
Bogolyubskii SI Origin and transformation pets. M. Sov. nauka, 1959. 593 p.
[81]
Schwartz S. Problems of domestication of plants and animals. Moscow: Nauka, 1972. 316 p.
[82]
Belyaev DK. Genetics and breeding of new breeds of farm zhivotnyh. Alma-Ata: Nauka, 1970. 145 p.
[83]
Stolina MR, Solomko AP. Analysis of female reproductive function of laboratory mice CC57W. MV m Chernobyl and Kiev populyat. Actual problems of the influence of ionizing radiation on the reproductive function: Proc. of reports. conf. CIS. Obninsk, 1992: 69-70.
[84]
Amvrosev AP, Banetskaya NV. Near and long-term affects of the combined effects of iodine-131 and cesium-137 in low dose to the ovaries of animals. Dokl. Acad nauk Belarus. 1992; 36(9-10):855-8.
[85]
Malashenko AM, Semenov KhKh. Role of female genotype in manifestation of dominant lethal mutations induced by thiophosphamide in the spermatids of male rats. Genetika. 1980;16(11):2002-8.
[86]
Pomerantseva MD, Shevchenko VA, Ramaĭia LK, Testov BV. Genetic damage in domestic mice inhabiting in the areas with elevated background radiation. Genetika. 1990;26(3):466-73.
[87]
Balonov MI, Chetchueva ME, Pomerantseva MD, Ramaja LK. The mutagenic effect of 3H thymidine on germ cells of male mice. Genetika. 1992; 28(3):147-54.
[88]
Stolina MR. Genetic effects in mice of line OC57W. Mv, induced by chronic low doses of ionizing radiation: Author. Thesis. ... candidate. Biol. nauk. Kyiv, 1994. 20 p.
[89]
Solomko AP, Stolina MR. Genetic effects in male laboratory mice Chernobyl population CC57W. Mv, induced by low doses of radiation. Actual problems of influence (ionizing radiation. Reproductive function: Proc. Dokl. Conf. CIS. Obnisk, 1992: 67.
[90]
Stolina MR. Chronic influence effect of cooperative low-dosed irradiation on reproductive function of CC57W males and females mice. Biopolym Cell. 1993; 9(3):49-52.
[91]
Stolina MR, Glazko TT, Solomko AP, Maluta SS, Glazko VI. The influence of the low-dose ionizing radiation at the initial stages of embryo development in mice. Dopovidi Akad Nauk Ukrainy. 1993;(6):171-6.
[92]
Evsykov SV, Morozova LM, Solomko AP. Role of the nucleocytoplasmic ratio in the regulation of the mammal development. Development of zygotes with a decreased cytoplasm volume. Biopolym Cell. 1989; 5(5):87-93.
[93]
Goldbard SB, Warner CM. Genes affect the timing of early mouse embryo development. Biol Reprod. 1982;27(2):419-24.
[94]
Lutz SE, Hilbish TJ, Dewey MJ. Genetic control of juvenile growth rate in mice: variation between a congenic strain and its background strain. J Hered. 1989;80(4):264-7.
[95]
Morozova L. M., Stolina M. R., Solomko A. P. Optimization of the system for genetic-embryological studies of inbred mice strains. 2. Comparative characterization of season female fertility of BALB/cLac, C57BL/6j and ICR mice. Biopolym Cell. 1992; 8(3):33-36.
[96]
Chaillet JR, Vogt TF, Beier DR, Leder P. Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell. 1991;66(1):77-83.
[97]
Billen D. Spontaneous DNA damage and its significance for the "negligible dose" controversy in radiation protection. Radiat Res. 1990;124(2):242-5.
[98]
Bedford JS. Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations. Int J Radiat Oncol Biol Phys. 1991;21(6):1457-69.