The proteins secondary structure prediction by the modified GUHA-method

Authors

  • A. V. Bratus Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • S. Z. Maltchenko Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • N. A. Chaschin Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author

DOI:

https://doi.org/10.7124/bc.000373

Abstract

A new method for protein secondary structure prediction is described in the present article. This method based on GUHA-method has been known in the field X-ray resolution less than 0,2 nm was used for learning and prediction of protein secondary structure. Average accuracy of prediction for α-helix is 74 %, β- strand is 67 %, coil is 71 % and for three states simultaneously is 68 % of successful prediction.

References

Sternberg MJ, Islam SA. Local protein sequence similarity does not imply a structural relationship. Protein Eng. 1990;4(2):125-31.

Hajek P, Havranek T. Mechanizing Hypothesis Formation: Mathematical Foundations for a General Theory. Springer; 1978 416 p.

Maltchenko SZ, Chaschin NA. Prediction of protein secondary structures. Biopolym Cell. 1992; 8(5):21-31.

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Published

1993-09-20

Issue

Vol. 9 No. 5 (1993)

Section

Structure and Function of Biopolymers