New 6-azauracil derivatives – amides of as-triazine carbon acids: their synthesis and antimicrobial activity
DOI:
https://doi.org/10.7124/bc.000604Abstract
Three series of new 6- azauracil derivatives, differing by structural motives of the spacer linking a heterocycle with carbamide fragments have been synthesized and researched on the basic principles of bioisosterism concept. The antimicrobial activity of these new compounds has been detected in test-cultures of bacteria, micelial and yeast-like fungi. The results obtained indicate that the 6-azauracil-5-propanic and 5-thioacetic acid derivatives can be modified to enhance significantly their antibacterial potency.References
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