Biopolym. Cell. 1991; 7(6):15-32.
Структура та функції біополімерів
Можливості м’якоіонізаційної мас-спектрометрії у молекулярно-біологічних дослідженнях
1Суходуб Л. Ф.
- Інститут прикладної фізики HAH України
вул. Петропавлівська, 58, Суми, Україна, 40030
Abstract
В огляді зібрано дані, що демонструють можливості м'якоіонізаційної мас-спектрометрії (MI-MC) в молекулярно-біологічних дослідженнях у двох напрямках: термодинамічному та структурно-аналітичному.
Описано методику температурно-залежної мас-спектрометрії поля, за допомогою
якої вперше поставлено експерименти по вимірянню термодинамічних характеристик
ряду біологічних асоціатів: уотсон-криківських, «неправильних» та інших пар основ,
купкові дімери основ, комплекси «амінокислота–основа», гідрати основ та їх пар.
Зроблено аналіз цих даних в поєднанні з теорією.
Показано перспективи MI-MC у вивченні продуктів гідролізу (розпаду) лікувальних препаратів у фізіологічному розчині та аддуктів їх взаємодії з ДНК.
Повний текст: (PDF, російською)
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