Biopolym. Cell. 2019; 35(4):249-267.
http://dx.doi.org/10.7124/bc.000A08
Огляди
Фотосенсибілізаторина основі наночастин з ефектом агрегаційно-індукованої емісії
1Корнеев О. В., 2Сахно Т. В., 2Короткова І. В.
  1. Вищий державний навчальний заклад України «Українска медична стоматологічна академія»
    вул. Шевченко, 23, Полтава, Україна, 36024
  2. Полтавська державна аграрна академія
    вул. Сковороди, 1/3, Полтава, Україна, 36000

Abstract

Фотодинамічна терапія (ФТД) – це метод лікування локалізованих видів раку, що заснований на фотохімічній реакції між активованою світлом молекулою або фотосенсибілізатором (ФС), світлом і молекулярним киснем. Вирішальне значення для забезпечення ефективності ФДТ має правильно обраний ФС. Незважаючи на численні дослідження в цьому напрямку, більшість відомих ФС мають ряд недоліків, такі як відсутність специфічності і агрегація в водних середовищах. Отже, пошук ідеального ФС – актуальне завдання для подальшого розвитку ФДТ. У цьому огляді представлено класифікацію і аналізуються основні особливості ФС різних поколінь, описано механізми їх дії. Обговорюються різні способи здійснення адресної доставки ФС до пухлинних клітин. Описано переваги наночастин ФС з ефектом агрегаційно-індукованої емісії (АІЕ) відносно вихідних фотосенсибілізаторів.Показана можливість використання таких світловипромінюючих структур для практичного застосування в фототерапії раку.
Keywords: фотодинамічна терапія, фотосенсибілізатор, агрегаційно-індукована емісія
Повний текст: (PDF, англійською)

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